نتایج جستجو برای: human coagulation Factor VIII

تعداد نتایج: 2336393  

Journal: :iranian journal of pediatric hematology and oncology 0
fatemeh sarkargar phd student of biochemistry, department of biology, faculty of science, payamnoor -university, tehran, ira mahta mazaheri associate professor of medical genetics (md-phd), department of genetics, faculty of medicine, shahid sadoughi universiسازمان های دیگر: mother and newborn health research center, shahid sadoughi university of medical science, yazd, iran hossein khodai expert laboratory of genetic, meybod genetic research center, meybod, iranسازمان اصلی تایید شده: دانشگاه پیام نور تهران (payame noor university) razieh sadat tabatabaei assistant professor of gynecology, department of gynecology and obstetrics, faculty of medicine, shahid sadoughi universسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید صدوقی یزد (shahid sadooghi university of medical sciences)

background: haemophilia a (ha) is an x-linked bleeding disorder caused by the absence or reduced activity of coagulation factor viii (fviii). coagulation factors are a group of related proteins that are essential for the formation of blood clots. the aim of this study was to genotype the coagulation factor viii gene mutations using inverse shifting pcr (is-pcr) in an iranian family with severe ...

ALI AKBAR POURFATHOLLAH, HABIBOLLAH ESMAILI, HASSAN MANSOURI TORGHABEH, MAHMOOD MAHMOODIAN SHOOSHTARI, ZAHRA REZAIE YAZDI,

Patients with coagulation factor(s) deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor(s). In this survey we detected factor V and VIII inhibitor in ten patients with combined deficiency of factors V and VIII from north east of Iran (Khorassan province). It was revealed in our survey that eight patients had both factor V and factor VIII i...

Journal: :medical journal of islamic republic of iran 0
hassan mansouri torghabeh from the 'experimental hematology and blood banking dept, medical sciences school, tarbiat modaresuniversity (t.m. u.), ali akbar pourfathollah from the 'experimental hematology and blood banking dept, medical sciences school, tarbiat modaresuniversity (t.m. u.), mahmood mahmoodian shooshtari the iranian blood transfusion organization research center, tehran zahra rezaie yazdi the departmentof internal medicine, mashhad medical sciences university, mashhad habibollah esmaili 4community medicine and public health department of mashhad medical sciences university, mashhad, iran

patients with coagulation factor(s) deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor(s). in this survey we detected factor v and viii inhibitor in ten patients with combined deficiency of factors v and viii from north east of iran (khorassan province). it was revealed in our survey that eight patients had both factor v and factor viii inhib...

Context:  The major motivation for the preparation of the plasma derived biological medicine was the treatment of casualties from the Second World War.  Due to the high expenses for preparation of plasma derived products, achievement of self-sufficiency in human plasma biotechnological industry is an important goal for developing countries.Evidence Acquisition:  The complexity of the bloo...

Journal: :arya atherosclerosis 0
s asgary a poorshams gh naderi ah siadat n askari

abstract  introduction: during extrinsic coagulation pathway, a complex is developed between factor vii, calcium and tissue factor (a cell membrane lipoprotein that is exposed after cell injury). factor vii needs calcium and vitamin k for its biologic activation. coronary artery disease (cad) can be induced by increased level and activity of the coagulation factors vii, viii and ix. in postmeno...

ذوالفقاری, سیما , صادقی, معصومه , عسکری, نازیلا , عسگری, صدیقه , فاضلی, مریم , نادری, غلامعلی, پورشمس, اکرم ,

Background: During extrinsic coagulation pathway, a complex is developed between factor VII, calcium and tissue factor (a cell membrane lipoprotein that is exposed after cell injury). Factor VII needs calcium and vitamin K for its biologic activation. Coronary artery disease can be induced by increased level and activity of the coagulation factors VII, VIII and IX. In postmenopausal period, est...

Journal: :Acta biochimica Polonica 2016
Anna Mazurkiewicz-Pisarek Grażyna Płucienniczak Tomasz Ciach Andrzej Płucienniczak

Factor VIII (FVIII), an essential blood coagulation protein, is a key component of the fluid phase blood coagulation system. Human factor VIII is a single chain of about 300 kDa consisting of domains described as A1-A2-B-A3-C1-C2. The protein undergoes processing prior to secretion into blood resulting in a heavy chain of 200 kDa (A1-A2-B) and a light chain of 80 kDa (A3-C1-C2) linked by metal ...

Journal: :Progress in clinical and biological research 1981
L W Hoyer

Normal human plasma contains a complex of two proteins that are important in hemostasis and coagulation. The factor VIII procoagulant protein (antihemophilic factor) and the factor VIII-related protein (von Willebrand factor) are under separate genetic control, have distinct biochemical properties, and have unique and essential physiologic properties. While the nature of their interaction and t...

Protein specific aptamers are highly applicable affinity ligands in different fields of research and clinical applications. They have been developed against various targets, in particular, bio-macromolecules such as proteins. Among human proteins, the coagulation factors are the most attractive targets for aptamer selection and their specific aptamers had valuable characteristics in therapeutic...

Protein specific aptamers are highly applicable affinity ligands in different fields of research and clinical applications. They have been developed against various targets, in particular, bio-macromolecules such as proteins. Among human proteins, the coagulation factors are the most attractive targets for aptamer selection and their specific aptamers had valuable characteristics in therapeutic...

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