نتایج جستجو برای: hif1α

تعداد نتایج: 905  

سهراب حاجی زاده, فیروزه علویان محمد جوان, محمدرضا بیگدلی

زمینه و هدف: اخیراً نشان داده شده هیپراکسی نورموباریک اثر درمانی قابل ملاحظه‌ای در درمان ایسکمی حاد دارد که اصطلاحاً پیش شرطی‌سازی نامیده می‌شود. به هر حال به خوبی مشخص نیست این پیش‌شرطی در محیط زنده چگونه عمل می‌کند. در مطالعه حاضر اثر هیپراکسی نورموباریک متناوب بر بیان HIF1α در مدل سکته مغزی مورد مطالعه قرار گرفت. مواد و روش‌ها: مطالعه از نوع تجربی بوده و حیوانات شامل4 گروه، هر گروه شامل 6 موش...

2015
Dessislava N. Mladenova Jane E. Dahlstrom Phuong N. Tran Fahad Benthani Elaine G. Bean Irvin Ng Laurent Pangon Nicola Currey Maija R. J. Kohonen-Corish

Hypoxia-inducible factor 1α (HIF1α) is a transcription factor that regulates the adaptation of cells to hypoxic microenvironments, for example inside solid tumours. Stabilisation of HIF1α can also occur in normoxic conditions in inflamed tissue or as a result of inactivating mutations in negative regulators of HIF1α. Aberrant overexpression of HIF1α in many different cancers has led to intensiv...

2013
Weranja K. B. Ranasinghe Lin Xiao Suzana Kovac Mike Chang Carine Michiels Damien Bolton Arthur Shulkes Graham S. Baldwin Oneel Patel

BACKGROUND Castrate-resistant prostate cancer (CRPC) is a lethal condition in patients receiving androgen deprivation therapy for prostate cancer (PC). Despite numerous studies showing the expression of HIF1α protein under normoxia in PC cell lines, the role of this normoxic HIF1α expression in chemo-resistance and migration has not been investigated previously. As no method is currently availa...

2016
Alain de Bruin Peter W. A. Cornelissen Bettina C. Kirchmaier Michal Mokry Elhadi Iich Ella Nirmala Kuo-Hsuan Liang Anna M. D. Végh Koen T. Scholman Marian J. Groot Koerkamp Frank C. Holstege Edwin Cuppen Stefan Schulte-Merker Walbert J. Bakker

In this study, we explored the existence of a transcriptional network co-regulated by E2F7 and HIF1α, as we show that expression of E2F7, like HIF1α, is induced in hypoxia, and because of the previously reported ability of E2F7 to interact with HIF1α. Our genome-wide analysis uncovers a transcriptional network that is directly controlled by HIF1α and E2F7, and demonstrates both stimulatory and ...

ژورنال: :مجله علمی - پژوهشی دانشگاه علوم پزشکی سبزوار 1970
سهراب حاجی زاده محمد جوان محمدرضا بیگدلی فیروزه علویان

زمینه و هدف: اخیراً نشان داده شده هیپراکسی نورموباریک اثر درمانی قابل ملاحظه ای در درمان ایسکمی حاد دارد که اصطلاحاً پیش شرطی سازی نامیده می شود. به هر حال به خوبی مشخص نیست این پیش شرطی در محیط زنده چگونه عمل می کند. در مطالعه حاضر اثر هیپراکسی نورموباریک متناوب بر بیان hif1α در مدل سکته مغزی مورد مطالعه قرار گرفت. مواد و روش ها: مطالعه از نوع تجربی بوده و حیوانات شامل4 گروه، هر گروه شامل 6 موش...

Journal: :Cancer discovery 2011
Chuan Shen Rameen Beroukhim Steven E Schumacher Jing Zhou Michelle Chang Sabina Signoretti William G Kaelin

UNLABELLED Kidney cancers often delete chromosome 3p, spanning the VHL tumor suppressor gene, and chromosome 14q, which presumably harbors ≥ 1 tumor suppressor genes. pVHL inhibits the hypoxia-inducible transcription factor (HIF), and HIF2α is a kidney cancer oncoprotein. In this article, we identify focal, homozygous deletions of the HIF1α locus on 14q in clear cell renal carcinoma cell lines....

2017
Ting Wang Huiying Liu Guan Lian Song-Yang Zhang Xian Wang Changtao Jiang

Hypoxia-inducible factor (HIF) 1α is a metabolic regulator that plays an important role in immunologic responses. Previous studies have demonstrated that HIF1α participates in the M1 polarization of macrophages. To clarify the mechanism of HIF1α-induced polarization of M1 macrophage, myeloid-specific HIF1α overexpression (Lysm HIF1α lsl) mice were employed and the bone marrow-derived and perito...

Journal: :Scientific reports 2016
Ning Liu Wu-Yan Xia Shan-Shan Liu Hai-Yan Chen Lei Sun Meng-Yao Liu Lin-Feng Li Hong-Min Lu Yu-Jie Fu Pei Wang Hailong Wu Jian-Xin Gao

The activation/inactivation of HIF1α is precisely regulated in an oxygen-dependent manner. HIF1α is essential for hypoxia induced apoptosis and cell cycle arrest. Several recent studies indicated that the expression of miRNAs can be modulated by hypoxia. However, the involvement of miRNAs in the regulation of HIF1α induction remains elusive. In present study, we demonstrated that miR-101 was ra...

2015
Yi Ran No Sei-Jung Lee Ajay Kumar C. Chris Yun Dennis J. Templeton

Macrophage migration inhibitory factor (MIF) is a cytokine that has broad effects on immune system and inflammatory response. A growing body of evidence implicates the role of MIF in tumor growth and metastasis. Lysophosphatidic acid (LPA), a bioactive lipid mediator, regulates colon cancer cell proliferation, invasion, and survival through LPA2 receptor. Loss of LPA2 results in decreased expre...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2010
Asima Bhattacharyya Ranajoy Chattopadhyay Emily H Hall Semret T Mebrahtu Peter B Ernst Sheila E Crowe

Hypoxia-inducible factor 1 (HIF1) consists of a hypoxia-inducible α subunit and a constitutively expressed β subunit. Reactive oxygen species (ROS) induced by Helicobacter pylori stabilize HIF1α in the human gastric epithelium in normoxia. HIF1α plays crucial role in carcinogenesis and has been associated with malignant progression of gastric cancer. Several genes contain functional hypoxia-res...

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