OBJECTIVES To evaluate HER2neu and epidermal growth factor receptor (EGFR) expression with respect to overall survival and disease-free survival (DFS), and correlate expression with pretreatment factors. Comparative evaluations of manual and automated immunohistochemical imaging systems for HER2neu and EGFR expression were made. METHODS Fifty-five patients with stages I-IVA carcinoma of the c...

AIMS HER2NEU gene amplification is present in the majority of invasive breast carcinomas that have HER2 protein overexpression. A subset of breast cancers harbour an increased chromosome 17 (CEP17) copy number (polysomy 17). We investigated the clinicopathologic significance of polysomy 17 in correlation with various histological parameters and HER2NEU gene amplification. METHODS We collected...

INTRODUCTION Breast cancer aggressiveness can be correlated with proliferation status of tumor cells, which can be ascertained with tumor grade and Ki67 indexing. However due to lack of reproducibility, the ASCO do not recommend routine use of Ki67 in determining prognosis in newly diagnosed breast cancers. We therefore aimed to determine associations of the Ki67 index with other prognostic mar...

After a long period of therapeutic stagnation, significant breakthrough in the treatment adenocarcinomas gastroesophageal junction (GEJ) and stomach (GC) is now becoming evident with implementation Her2neu-based targeted therapies (trastuzumab trastuzumab-deruxtecan) use PDL1 checkpoint inhibitors (nivolumab, pembrolizumab).The required companion diagnostics regarding Her2neu overamplification ...

Цель. Оценить прогностическое значение суррогатных молекулярно-биологических подтипов при РМЖ по данным Архангельского областного канцер-регистра (АОКР) в период 2010-2020 гг. Материалы и методы. Сплошная выборка записей о больных раком молочной железы из базы данных совмещена с данными иммуногистохимического исследования патологоанатомической данных, включая уровни рецепторов эстрогенов, проге...

AIM The aim of the study was to identify the impact of T stage, the presence of estrogen, progesterone, HER2neu receptors and the values of the Ki67 on the positivity for metastases of the axillary lymph nodes, from primary breast cancer. MATERIAL AND METHODS 290 surgically treated patients for breast cancer were included in the study. All cases have been analyzed by standard histological ana...

AIM The study aimed to identify factors that influence the positivity of axillary lymph nodes in patients with early breast cancer and clinically negative axillary lymph nodes, who were subjected for modified radical mastectomy and axillary lymphadenectomy. MATERIAL AND METHODS This study included 81 surgically treated, early breast cancer patients during the period from 08-2015 to 05-2017. A...

Background: Triple-negative breast cancer (TNBC) is defined as absent expression of estrogen receptor (ER) and progesterone receptors human epidermal growth factor (HER2neu). These cancers are associated with poor prognosis. Aims Objectives: We aimed at to study the clinicopathological profile survival among women TNBC. Materials Methods: The was conducted over a period 4 years. Surgical specim...