Background: It is now well established that several environmental stress factors cause activation of p38 MAP kinase and JNK in various cell types to produce chemokines. Objective: To investigate the expression of CXC chemokines Gro/KC and SDF- 1a in rat's H4 hepatoma cells in response to heat shock, hyperosmolarity and oxidative stress. Methods: Hepatoma cells were maintained in MEM medium. Cel...

background and objectives: significant progress has been made in treatment of hemophilia. ex-vivo gene therapy is going popular due to the capability of this method in using isogenic cells for genetic manipulation and reintroducing them into same host after proliferation. most gene therapy techniques use viral vectors, which usually harbor a strong and non-specific promoter (e.g. cmv early prom...

background: it is now well established that several environmental stress factors cause activation of p38 map kinase and jnk in various cell types to produce chemokines. objective: to investigate the expression of cxc chemokines gro/kc and sdf- 1a in rat's h4 hepatoma cells in response to heat shock, hyperosmolarity and oxidative stress. methods: hepatoma cells were maintained in mem medium...

conclusions taken together, these data reveal that cellular protease of chicken liver cells allows the replication of high yields of h9n2 virus in the absence of trypsin and also cell death in the infected cells is due to necrosis. results the degree of viability was significantly reduced in infected hepatoma cells. observations of caspase activation and cell dna laddering in infected cells wer...

Abstract Background Hepatoma is a common malignancy of the liver. The abnormal high expression alpha-fetoprotein (AFP) intimately associated with hepatoma progress, but mechanism transcriptional regulation and singularly activation AFP gene in not clear. Methods transcription factor HBP1 clinical significance were further analyzed tissues from patients who received surgery or TACE then monitore...

Purpose: To investigate the effect of excisanin A on human hepatocellular carcinoma cells as well to elucidate its mechanism action.
 Methods: Molecular docking was used determine binding characteristics HIF-1α protein. The transcriptional activation and viability were assessed using Luciferase reporter MTT assay. protein in nucleus assayed western blot immunofluorescence. VEGF mRNA levels...

Hepatoma cells derived from liver carcinoma are a candidate cell source for bioartificial (BAL) systems due to their high proliferative capacity, although function of hepatoma is considerably low compared with primary hepatocytes. In our previous study, genetically engineered mouse inducible were established by transducing liver-enriched transcription factor (LETF) genes. this we aimed develop ...

Sesquiterpenoid tagitinin C, present in Tithonia diversifolia leaves, has been known to have anti-hepatoma properties. Therefore, we investigated the anti-metastatic potential of C xenograft models hepatocellular carcinoma (HCC). We isolated from a methanolic extract leaves T. diversifolia. HepG-2 and Huh 7 hepatoma cells were treated with cell viability, migration, matrix metalloproteinase (MP...