Introduction: Hepatocellular carcinoma (HCC) is sixth common cancers worldwide and predominant in Asia and Africa. A number of evidence suggests a possible role of midkine (MDK) and α-fetoprotein (AFP) in the pathogenesis of hepatocellular carcinoma (HCC). Materials and methods: We studied MDK and AFP in patients with HCC or in healthy controls. MDK and AFP was measured by enzyme linked immuno...

hepatocellular carcinoma (hcc) is very rare during pregnancy and has a worse prognosis in pregnant women compared to those who are not pregnant. we present a case of hcc in a 41- year-old pregnant patient who was referred to our academic hospital. the patient presented with chief complaints of abdominal pain, jaundice, edema and hypertension. laboratory results were notable for elevated liver e...

hepatocellular carcinoma (hcc) is the most common, malignant tumor of the liver. hepatocellular carcinoma (hcc) commonly metastasizes to the lungs, abdominal lymph nodes, adrenal glands, or bones. distant lymph node metastases are rare in hepatocellular carcinoma. a 49-year-old male patient presented with right sided neck mass. on examination there was right cervical lymphadenopathy and hepatom...

introduction : fibrolamellar carcinoma (flc), a subtype of hepatocellular carcinoma (hcc), is a rare primary hepatic malignancy. several aspects of the clinical features and epidemiology of flc remain unclear since most literature on flc consists of case reports and small cases series with limited information on factors that affect survival. majority of the tumors occurred in patients less than...

background: hepatocellular carcinoma (hcc) is a primary liver cancer that frequently causes mortalities. transarterial chemoembolization (tace) is a new palliative treatment for advanced stages of hcc. in this study, we have assessed the results of tace on a group of iranian patients with advanced hcc treated at imam khomeini general hospital. materials and methods: this was a case series, coho...

Discrimination of regenerative cirrhotic nodules of the liver (CN) from hepatocellular carcinoma (HCC) is sometimes difficult. We examined the utility of AgNOR staining in this context. Fifteen cases of HCC and 25 cases of CN were stained by AgNOR method and the mean AgNOR number for one hundred nuclei in each case was determined. There was a significant difference between the mean AgNOR c...

background: the association between hepatitis b virus (hbv) mutations and hepatocarcinogenesis were reported in the literature. preference for g over c in the leading dna strand has been reported to account for the asymmetry in nucleotide (nt) composition. the aim of this study was to analyze the complete genome sequence and compositional asymmetry of hbv in different stages of hepatitis b. met...

introduction: hepatocellular carcinoma (hcc) is sixth common cancers worldwide and predominant in asia and africa. a number of evidence suggests a possible role of midkine (mdk) and α-fetoprotein (afp) in the pathogenesis of hepatocellular carcinoma (hcc). materials and methods: we studied mdk and afp in patients with hcc or in healthy controls. mdk and afp was measured by enzyme linked immunos...

Background: Hepatocellular carcinoma (HCC) is common all over the world as well as Iran. The incidence of HCC is higher in hepatitis B carriers and it is highly recommended to periodically screen these patients by serum alpha-fetoprotein (AFP) and liver ultrasound (US) every 6 months. We explore the diagnostic accuracy and the performance of (AFP) in cases of hepatitis B carriers as a scree...