hepatoblastoma (hb) is a rare tumor of infancy and childhood manifesting with hepatomegaly and abdominal distention. it is seen with increased frequency in association with congenital hemihypertrophy and renal anomalies. metastases to other organs, including the lungs, lymph nodes and even ovaries is well known. but cerebral metastasis of this tumor, especially in the absence of metastasis to o...

The aim of this study was to investigate the expression of CD44 and its clinical significance in children suffering from hepatoblastoma (HB). CD44 expression was detected with immunohistochemistry staining in 30 samples from hepatoblastoma children and 10 normal liver tissue samples from normal children. The data obtained was statistically analyzed using the chi-square test, using the SPSS (v.1...

UNLABELLED This study is to review and retrieve data on adult hepatoblastoma (HB) from English literatures in order to gain a better understanding of this disease. We performed Medline, PubMed (from January 1966 to February 2008), and library searches (National Science and Technology Library, Beijing, China, and Wenzhou Medical College Library, from January 1980 to February 2008) using the key ...

Background: In the past 20 years, a dramatic improvement in the prognosis of patients with hepatoblastoma (HB)has been achieved by combining surgery and chemotherapy in several national and international trials.Materials and Methods: Four children ( 3 girl and 1 boy) aged 34 days, 4 months, 13 months, and 1 year with meanage of 6.53 (±5.15) months were presented to our center from 2002 to 2009 ...

background: in the past 20 years, a dramatic improvement in the prognosis of patients with hepatoblastoma (hb)has been achieved by combining surgery and chemotherapy in several national and international trials.materials and methods: four children ( 3 girl and 1 boy) aged 34 days, 4 months, 13 months, and 1 year with meanage of 6.53 (±5.15) months were presented to our center from 2002 to 2009 ...

Introduction: Hepatoblastoma (HB) is the most common primary malignant liver neoplasm in children. Its increasing survival rate is related to the progress in modern imaging, surgical techniques, and new chemotherapy regimens. Clinical approach: One of the past achievements was the development of the pretreatment extension of disease (PRETEXT) system. Gradually, the HB therapeutic approach has b...

NK cells are involved in the lysis of different solid tumors and leukemias. NK-activity is thereby regulated by activating and inhibitory receptors. Until now, nothing is known about the NK-activity against hepatoblastoma and the involved receptors. We tested NK cells for cytotoxicity against HB in vitro. Expression levels of activating NK ligands were analysed on 13 primary HB samples as well ...

Beckwith-Wiedemann Syndrome (BWS) and familial adenomatous polyposis (FAP) are known to predispose to hepatoblastoma (HB). A case-control study was conducted through the Children's Oncology Group (COG) to study the association of HB with isolated congenital abnormalities. Cases (N = 383) were diagnosed between 2000 and 2008. Controls (N = 387) were recruited from state birth registries, frequen...

Hepatoblastoma (HB) is a rare malignant tumour of the liver and usually occurs in the first three years of life. Hepatoblastoma in adolescents and young adults is extremely rare; nevertheless the prognosis is much worse than in childhood, because these kinds of tumours are usually diagnosed late. Characteristic imaging and histopathological and AFP levels help in the diagnosis of hepatoblastoma...

Hepatoblastoma (HB) is a rare tumor of infancy and childhood manifesting with hepatomegaly and abdominal distention. It is seen with increased frequency in association with congenital hemihypertrophy and renal anomalies. Metastases to other organs, including the lungs, lymph nodes and even ovaries is well known. But cerebral metastasis of this tumor, especially in the absence of metastasis ...