background: this study was carried out to observe the radioprotective effects of rosemarinus officinalis leaves extract (roe) against radiation-induced histopathological alterations in liver of mice. materials and methods: adult swiss albino mice were exposed to 6 gy gamma radiation in the presence (experimental) or absence (control) of roe to study the qualitative and quantitative alterations ...

Background: Workers in different occupational positions experience significant Cu exposures, however, Cu toxicity has not been fully studied as compared to other heavy metals. In the present study, hematological and hepatic alterations have been investigated among copper mine workers. Materials and Methods: This descriptive study was conducted in a copper mine in west of Iran, on 402 copper mi...

aim : in this study, to clarify the smad4blocking impact on fibrosis process, we investigated its down-regulation by shrna on activated human lx-2 cell, in vitro.   background : liver fibrosis is a critical consequence of chronic damage to the liver that can progress toward advanced diseases, liver cirrhosis and hepatocellular carcinoma (hcc).  different smad proteins play as major mediators in...

Correspondence Figure 1. Frequency of early symptomatic hepatic events in controlled and uncontrolled trials with nevirapine. Data are from Boehringer Ingelheim's Expanded Hepatic Analysis and are included in EU/US VIRAMUNE prescribing information; " early symptomatic events " refers to events occurring during the first 6 weeks of treatment. To the Editor—The recent article by Sanne et al. [1] ...

Background: Mutation in NPM1 gene has been reported to be the most common genetic mutation in de novo acute myeloid leukemia (AML). AML with NPM1 gene mutation usually presents with higher initial leukocyte and blast cell counts and negative CD34 expression. We aimed to investigate the difference of initial leukocyte counts, bone marrow blast cell counts and expression of CD34 among patients wi...

Haematological, hepatic and oxidative stress parameters in juvenile Clarias gariepinus exposed to a combined ternary mixture of naphthalene, phenanthrene benzo[a]pyrene were investigated under static-renewal bioassay conditions. The test organisms two levels treatments the mixed compounds for period 35 days. Red blood cell (RBC) count, haemoglobin (Hb) concentration haematocrit (Hct) significan...

Currently, the optimal therapy of primary liver cancer (PLC) remains to be hepatic resection. For better management of the patients, we evaluated the prognostic predicting value of red blood cell (RBC) count, a routine laboratory parameter, on the long-term survival of patients who underwent surgical treatment. Clinical and laboratory data of 758 patients, who underwent surgical hepatic resecti...