helitropium europaeum l. population garmsar was shown to contain three major alkaloids: heliotrine n-oxide (2), lasiocarpine (4) and lasiocarpine n-oxide (5); and four minor alkaloids: heliotrine (i), europine (3), acetyllasiocarpine (6) and a novel alkaloid acetyllasiocarpine n-oxide (7).

Helitropium europaeum L. population Garmsar was shown to contain three major alkaloids: heliotrine N-oxide (2), lasiocarpine (4) and lasiocarpine N-oxide (5); and four minor alkaloids: heliotrine (I), europine (3), acetyllasiocarpine (6) and a novel alkaloid acetyllasiocarpine N-oxide (7).

background and objectives: the plants belonging to the genus heliotropium l. (boraginaceae) are the main sources of toxic pyrrolizidine alkaloids (pas). in the present study, we have investigated the pas of the aerial parts of heliotropium transoxanum bunge, a perennial species native to iran. methods: silica gel column chromatography and silica gel ptlc were applied for the isolation of pas pr...

A reverse-phase high-performance liquid chromatography method utilizing evaporative light scattering detection (ELSD) has been developed for the simultaneous detection of hepatotoxic pyrrolizidine alkaloids with and without chromophores, namely, riddelliine, riddelliine N-oxide, senecionine, senecionine N-oxide, seneciphylline, retrorsine, integerrimine, lasiocarpine and heliotrine. Pyrrolizidi...

M. Wink* Universität München, Pharmazeutische Biologie, Karlstraße 29, D-8000 München 2, Bundesrepublik Deutschland D. Schneider Max-Planck-Institut für Verhaltensphysiologie, D-8131 Seewiesen, Bundesrepublik Deutschland L. Wit te Technische Universität Braunschweig, Institut für Organische Chemie, Hagenring 30, D-3300 Braunschweig, Bundesrepublik Deutschland Z. Naturforsch. 43c, 737-741 (1988)...

Background and objectives: The plants belonging to the genus Heliotropium L. (Boraginaceae) are the main sources of toxic pyrrolizidine alkaloids (PAs). In the present study, we have investigated the PAs of the aerial parts of Heliotropium transoxanum Bunge, a perennial species native to Iran. Methods: Silica gel column chromatography and silica gel PTLC were applied ...

Three rats of six males, surviving 22 to 27.5 months after one or two intragastric doses of the monoester pyrrolizidine alkaloid, heliotrine (230 mg/kg body weight), and pretreatment with nicotinamide (350 mg/kg body weight) by pretreatment with nicotinamide (350 mg/kg body weight) by i.p. injections, developed pancreatic islet-cell tumors, accompanied in one of the rats by transitory cell papi...

Heliotropium indicum Linn., commonly known as ‘Indian heliotrope’, is a herb with pale violet flowers belonging to the family Boraginaceae and is very common in India with a long history of traditional medicinal uses in many countries in the world. It is distributed in the tropical and temperate regions of the world and found throughout India. The plant is reported to possess antibacterial, ant...

Earlier studies on the effects of heliotrine poisoning demonstrated an apparent deficiency of DPN in homogenate and mitochondrial preparations from the livers of heliotrine-poisoned (1620hr.) rats (Christie, 1958b). More recent work has shown that the concentrations of pyridine nucleotides were, in fact, decreased in homogenates and in the mitochondrial and soluble fractions of liver from rats ...