in order to study the effect of ultrasound (us) on bone healing, a complete transverse fracture was made in the right radius of adult male rabbits by a cutter. 52 rabbits were used: group i. control (n= 17): group 2. test (n:=: 15): group 3, intact (n= i) and group 4 (n= 12) who were examined only for evaluation of the cutter effects in detail. 7 animals were operated with a gigli saw. the test...

Healing of the bone is different with the other part of the body. Fracture healing is actually a bone regeneration with no scar tissues, where as in wound healing, injured tissue is replaced by  connective tissue which became a scar, Traditionally fracture healing is divided in to 4 stages: 1) Stage of inflammation; 2) Stage of soft callus; 3) Stage of hard callus and 4) Stage of remodeling. In...

      Background: Effects of estrogen on bone metabolism and its protective role on prevention of osteoporosis are well   documented. However, the efficacy of estrogen treatment on bone healing is not well investigated. The drug can be delivered both systemically or locally to the bone with differences in concentrations and side effects. The aim of this study was to investigate the effect of lo...

PURPOSE OF REVIEW Bone fracture healing is a complex physiological process relying on numerous cell types and signals. Inflammatory factors secreted by immune cells help to control recruitment, proliferation, differentiation, and activation of hematopoietic and mesenchymal cells. Within this review we will discuss the functional role of immune cells as it pertains to bone fracture healing. In d...

Osthole is a bioactive coumarin derivative and has been reported to be able to enhance bone formation and improve fracture healing. However, the molecular mechanism of Osthole in bone fracture healing has not been fully defined. In this study we determined if Osthole enhances bone fracture healing through activation of BMP2 signaling in mice. We performed unilateral open transverse tibial fract...

objective: to determine the effects of platelet rich plasma prp on healing rates of long bone non-:union: fracture. method: this was a randomized double-blind placebo controlled clinical trial being performed in a 12-month period. we included 75 adult (>18 years) patients suffering from long bone (femur, tibia, humerus and ulna) non-:union: fracture who were randomly assigned to receive 5ml prp...

since bone marrow has been shown to contain osteoprogenitor cells, an experiment was devised to test its effects when injected percutaneously into osteotomies sites in rabbit radii. in this experimental study, the osteogenicity and its effect on early bone repair of bone marrow grafts were investigated. the purpose of this study was to determine whether bone marrow grafted percutaneously led to...

background: effects of estrogen on bone metabolism and its protective role on prevention of osteoporosis are well   documented. however, the efficacy of estrogen treatment on bone healing is not well investigated. the drug can be delivered both systemically or locally to the bone with differences in concentrations and side effects. the aim of this study was to investigate the effect of local an...

abstract non-:union: occurs when bone healing ceases and does not continue without some type of intervention. classification of non-:union: is traditionally based on the amount of callus or bone healing at the fracture site. successful treatment of non-:union: often depends on appropriate reduction and realignment of the fracture, bone grafting if necessary, and stabilization. this may not be p...