نتایج جستجو برای: hbeag نوترکیب

تعداد نتایج: 3952  

ژورنال: :physiology and pharmacology 0
آرش آرش کیا فرزین روحوند انستیتو پاستور ایران، بخش هپاتیت و ایدز سیدمهدی سادات صفیه امینی سعید عندلیبی مهدی فروزنده

آلودگی به ویروس هپاتیت (hbv) b یکی از مسایل بهداشت جهانی است به طوری که در حال حاضر حدود 360 میلیون نفر در ایران به این ویروس آلوده اند. در میان آنتی ژنهای این ویروس، عملکرد فیزیولوژیک hbeag مثبت حضور این آنتی ژن بعنوان مارکر تکثیر ویروس در نظر گرفته می شود و احتمالا در پاتوژنز و پایداری بیماری نقش دارد در حالیکه در بیماران hbeag منفی، تفاوت قابل ملاحظه ای در سیر بالینی بیماری مشاهده نشده است. ...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تربیت مدرس 1379

در این پژوهش ژن hbeag از ژنوم کامل hbv سویه ayw با روش pcr جداسازی شد. محصول pcr پس از تخلیص و آنالیز با آنزیم های محدودکننده و انجام مراحل کلونینگ در وکتور puc18 جهت بررسی نهایی به وسیله واکنش های ترادف یابی(sequancing) با تکنیک alf مورد تایید قرار گرفت . در مرحله بعد ژن e آنتی ژن در وکتورهای بیانی phild2 و phils1 که وکتورهای دوسو(shuttle) برای مخمر pichia pastoris و باکتری e.coli می باشند، تح...

Journal: : 2022

Background: five clinical phases were described in patients with chronic (HBV) infection: HBeAg- positive HBV infection, CHB, HBeAg negative HBeAg-negative CHB and occult infection.
 Aim: This study aimed to determine the incidence of unclassified phase (gray zone) hepatitis B its significant practice. 
 Patients methods: The was conducted retrospectively on 109 patients' who have HBs...

Journal: :archives of clinical infectious diseases 0
seyed moayed alavian baqiyatallah research center for gastroenterology and liver diseases, baqiyatallah medical sciences university, tehran, ir iran; baqiyatallah research center for gastroenterology and liver diseases, baqiyatallah medical sciences university, tehran, ir iran. email: email: seyed mohammad miri baqiyatallah research center for gastroenterology and liver diseases, baqiyatallah medical sciences university, tehran, ir iran mohammad javad behzadnia baqiyatallah research center for gastroenterology and liver diseases, baqiyatallah medical sciences university, tehran, ir iran

background to evaluate the strength of association and to determine the best prediction of response in terms of sensitivity and specificity among quantitative baseline hbv-dna levels in blood serum in patients with chronic hepatitis b (chb) infection who treated with interferon-alpha-2b. patients and methods totally, 78 chb patients with serum hbv-dna>105 copies/ml were treated with interferona...

Journal: :The Journal of infectious diseases 2012
Tai-Chung Tseng Chun-Jen Liu Tung-Hung Su Hung-Chih Yang Chia-Chi Wang Chi-Ling Chen Stephanie Fang-Tzu Kuo Chen-Hua Liu Pei-Jer Chen Ding-Shinn Chen Jia-Horng Kao

BACKGROUND It is unclear whether hepatitis B e antigen (HBeAg) seroconversion induced by nucleos(t)ide analogues (NUC) has a prognosis that is similar to that of spontaneous HBeAg seroconversion. METHODS A total of 148 noncirrhotic NUC-induced HBeAg seroconverters were consecutively enrolled. A historical control of 407 noncirrhotic spontaneous HBeAg seroconverters was also recruited. We comp...

Journal: :Journal of clinical microbiology 2005
He-Jun Yuan Man-Fung Yuen Danny Ka-Ho Wong Siu-Man Sum Joke Doutreloigne Erwin Sablon Ching-Lung Lai

This study was performed to determine the factors for predicting the occurrence of acute exacerbation of hepatitis B virus infection in HBeAg-negative patients. Two hundred and sixteen patients with known times of HBeAg seroclearance were recruited. Liver biochemistry and virologic markers were monitored. Precore and core promoter mutations were determined by a line probe assay. The median age ...

Journal: :Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 2014
Jeyamani Ramachandran Ashrafali Mohamed Ismail Gaurav Chawla Gnanadurai John Fletcher Ashish Goel C E Eapen Priya Abraham

BACKGROUND AND AIMS There is paucity of Indian data regarding serum HBsAg levels (qHBsAg) in treatment-naïve chronic hepatitis B (CHB). This study was done to determine correlation of qHBsAg with hepatitis B e antigen (HBeAg) and hepatitis B virus (HBV) DNA levels and its ability to independently categorize subgroups of CHB. METHODS We studied 131 treatment-naive CHB patients and initially cl...

Journal: :The Journal of clinical investigation 1992
S L Tsai P J Chen M Y Lai P M Yang J L Sung J H Huang L H Hwang T H Chang D S Chen

T cell proliferative responses to hepatitis B virus-encoded envelope antigen (S + preS2 + preS1), recombinant core antigen (HBcAg), and natural hepatitis B e antigen (HBeAg) were examined in 22 HBeAg-positive patients with chronic type B hepatitis and 17 healthy hepatitis B surface antigen (HBsAg) carriers. The results showed that HBeAg-positive patients had (a) higher levels of T cell response...

Journal: :Antiviral therapy 2014
Annikki de Niet Louis Jansen Hans L Zaaijer Ursula Klause Bart Takkenberg Harry L A Janssen Tom Chu Rosemary Petric Hendrik W Reesink

BACKGROUND We studied whether hepatitis B surface antigen (HBsAg)/anti-HBs immune complex levels in chronic hepatitis B (CHB) patients receiving antiviral therapy could be used as a response marker at baseline (BL) or early during treatment to predict treatment outcome. METHODS An experimental array-based assay (immunological multi-parameter chip technology [IMPACT]; Roche Diagnostics, Penzbe...

2014
Brook G. Warner William G.H. Abbott Allen G. Rodrigo

HBeAg seroconversion is an important stage in the evolution of a chronic hepatitis B virus (HBV) infection that usually leads to control of viral replication and a reduced risk for liver cirrhosis and cancer. Since current therapies for the HBV-associated liver inflammation that is known as chronic hepatitis B (CHB). Rarely induce permanent HBeAg seroconversion, there is a need to understand th...

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