BACKGROUND Certain epidermal appendage tumors, including hyperplasias (hamartomas), adenomas, benign epitheliomas, primordial epitheliomas, and malignant tumors, can exhibit any stage of differentiation. Several molecules associated with tumorigenesis, such as Gli-1, pleckstrin homology-like domain, family A, member 1 (PHLDA-1), transforming growth factor (TGF)-β1, TGF-β2, and p63, are associat...

Basaloid follicular hamartoma (BFH) is a benign rare neoplasm of the hair follicles whose clinical and histo-logical appearance is very similar to basal cell carcinoma. Although these hamartomas are considered to be benign lesions, malignant differentiations have been reported. It may be generalized or localized, familial or sporadic, and BFH can be accompanied by systemic diseases. Although th...

A follicular origin for some skin tumors has been hypothesized in both humans and animal models. Because of its rapid and sensitive response to tumor promoter treatment, a v-Ha-ras transgenic (TG.AC) mouse line was used to determine the origins of epidermal papillomas. Using histological studies and transgene expression as a marker for papilloma development, we determined that pedunculated papi...

Pigmented epithelioid melanocytoma (PEM) is a tumor encompassing epithelioid blue nevus of Carney complex (EBN of CNC) and was previously termed animal-type melanoma. Histologically PEMs are heavily pigmented spindled and epithelioid dermal melanocytic tumors with infiltrative borders, however, their origin remains unclear. Stem cells for the epidermis and hair follicle are located in the bulge...

objectives: this study was designed to investigate the potential phyllanthus niruri extracts in promotion of hair growth. materials and methods: here, we studied the hair growth promoting activity of petroleum ether extract of p. niruri following its topical administration. alopecia was induced in albino rats by subcutaneous administration of testosterone for 21 days. evaluation of hair loss in...

BACKGROUND Hair restoration surgery is one of the most commonly performed cosmetic surgery procedure in men. The main aim of the study was to know the effect of follicular unit extraction (FUE) follicular unit extraction (FUE) on donor area in terms of hair mass/density. METHODS Ten male patients undergoing hair restoration by FUE were included. In each patient, ten boxes of 1 cm2 each were ...

introduction: adult stem cells are the group of cells which conserve their nature in tissues and organs among other cells. in recent years, the researchers reported the existence of stem cells on the bulge of hair follicles near to the smooth muscle. it is possible to differentiate these stem cells to neural cells by induction of shh, fgf, and ra factors. because of existence of these factors i...

Background and aim: The skin has some appendages that give origin to various tumors. These tumors are generally divided to pilosebaceous and sweat glands tumors according to embryologic and histological features. Clinical and histological characteristics of these tumors are also divergent. In addition, classification of them according to histological background has been changed considerably in ...

introduction: photobiostimulation with low level laser (lll) has been used in medicine for a long time and its effects have been shown in many diseases. some studies have evaluated the effect of lll on androgenic alopecia. one of the most important limitations of the use of lll in the treatment of alopecia is the requirement for multiple sessions, which is hardly accepted by patients. this stud...

Background: Hair follicle cycling usually associated with prominent changes in skin vascularization; through follicular dermal papilla production of angiogenic factors. The early response of hair follicles to ionizing irradiation (IR) is induction of early anagen hair and appearance of new hair formation. Material and Method: Fifty rats were equally divided into 2 groups; control and γ-rays (10...