Gain-of-function mutations of the receptor tyrosine kinase KIT play a key role in the pathogenesis of systemic mastocytosis (SM), gastrointestinal stromal tumors (GISTs), and some cases of acute myeloid leukemia (AML). Whereas KIT juxtamembrane domain mutations seen in most patients with GIST are highly sensitive to imatinib, the kinase activation loop mutant D816V, frequently encountered in SM...

High-molecular-weight glutenin subunits (HMW-GS) composition was analyzed by sodium-dodecyl-sulfatpolyacrilamid-gel electrophoresis (SDS-PAGE), while the quantitative determination of total HMW-GS was obtained by reversed phasehigh performance liquid chromatography (RP-HPLC). Considering HMW-GS composition, the most frequent subunits at Glu-A1 locus were N, at Glu-B1 locus 7+9 and at Glu-D1 loc...

In this article, we present a dynamical homotopical cancellation theory for Gutierrez-Sotomayor singular flows $\varphi$, GS-flows, on surfaces $M$. This generalizes the classical of Morse complexes smooth systems together with corresponding non-degenerate singularities. is accomplished by defining GS-chain complex $(M,\varphi)$ and computing its spectral sequence $(E^r,d^r)$. As $r$ increases,...

Grain quality currently represents a major problem in high yielding rice production in Iran and many other rice producing areas of the world. Quality assessment of rice involves the function of sensory tests and physicochemical determinations based on the chemical composition, cooking quality, gelatinization temperature and physical properties of cooked rice. These research genetic materials we...

Grain quality currently represents a major problem in high yielding rice production in Iran and many other rice producing areas of the world. Quality assessment of rice involves the function of sensory tests and physicochemical determinations based on the chemical composition, cooking quality, gelatinization temperature and physical properties of cooked rice. These research genetic materials we...

In addition to the time-dependence of the msd, also the self-part of the van Hove correlation function Gs(r, t) is an interesting measure to characterize anomalous diffusion. Here, Gs(r, t) is the probability that a particle has moved within a time span t a distance r. The Gs(r, t) for a proton on a surface (figure S1) shows that the surface displacement exhibits long-tailed behavior with respe...

recently, the most important topic in water management was to determine the effects of urban forests and green space on partitioning gross rainfall (gr) into the rainfall interception (i), stemflow (sf), and throughfall (tf). the main aim of this research was to quantify the seasonal variations [growing season (gs), and non-growing season (ngs)]) in i by individual fraxinus rotundifolia trees i...

A family of probability measures on the unit ball in R generates a family of generalized Steiner (GS-)points for every convex compact set in R. Such a ”rich” family of probability measures determines a representation of a convex compact set by GS-points. In this way, a representation of a setvalued map with convex compact images is constructed by GS-selections (which are defined by the GS-point...

OBJECTIVE To determine the construct validity of cadaveric temporal bones in mastoidectomy training. STUDY DESIGN A prospective observational study. METHODS Trainees from the North London otolaryngology training program performed step-wise modified radical mastoidectomy on cadaveric temporal bones under faculty supervision. Performance was assessed using a validated mastoidectomy assessment...