1. Adult (A x C(57)Bl/1)F(1) hybrids regularly show runt disease when injected with adult spleen cells from A strain donors. This also occurs when A strain spleen cells are administered to adult C(3)H mice made tolerant of A strain tissue in the neonatal period. 2. Mice undergoing the graft versus host reaction fail to form antibodies to an intraperitoneal challenge of T(2) bacteriophage. This ...

Under in vitro conditions spleen cells from nonirradiated F(1) hybrids, in which a (graft-vs.-host) (GVH) reaction had been induced with lymphoid cells of parental origin, lysed nonspecifically target cells, i.e., cells syngeneic or allogeneic to the parental genotypes. Furthermore, tumor cells exposed in vitro to spleen cells of F(1) hybrid mice undergoing GVH reaction had markedly decreased a...

When parental type lymphoid cells are injected into F1 hybrid animals there is usually a severe graft-vs .-host reaction (GVHR) . It has been shown that a proportion of animals will survive the acute episode, depending on the number of cells injected and the strain combination used, and that these animals are then tolerant to a second challenge by parental type cells (1) . We have previously sh...

The primary purpose of this study has been to validate the in vitro graft-vs.-host reaction as an experimental system. Time-dose studies have been presented for cells obtained from spleen, thymus, cortisone-treated thymus, inguinal lymph node, mesenteric lymph node, thoracic duct, and bone marrow cells. Both the degree of splenomegaly and the onset of spleen enlargement were found to be depende...

The graft versus host reaction (GVHR), which results from the injection of parental strain spleen cells beneath the kidney capsule of F(1) hybrid rats, is transferable during its developmental phase into F(1) hybrid hosts isogeneic with the primary host, but not into secondary hosts of the parental (donor) strain. Furthermore, the GVHR propagates but rarely in secondary hybrid hosts which are a...

Haemophagocytic reticulosis is characterized by pancytopenia and an increased mass of reticuloendothelial cells in various organs containing engulfed blood cells (see Buist, Jones, and Cavens, 1971; Oehmichen, Narita, and Roloff, 1972; Nezelof and Eliachar, 1973). The pathogenesis is obscure. Autoimmunity, primary histiocytic proliferation, and a graft versus host reaction have been suggested. ...