introduction: the fate of xenobiotics that is present, increasing day by day. the increasing fates altered or inhibit the metabolic activities like detoxification and biotransformation. methods: the present study highlights this slow biotransformation and detoxification on the basis of specific enzymes which have a say in assessment of mercuric chloride toxicity and modulation by panax ginseng ...

helicobacter pylori infection leads to different clinical and pathological outcomes in humans, including chronic gastritis and gastric neoplasia. it has been demonstrated that oxidative stress associated with inflammation plays an important role in gastric carcinogenesis. to evaluate the oxidative stress in h. pylori infection we studied the gastric juice levels of nitric oxide and the activiti...

objective: to determine the relationship between serum glutathione peroxidase and febrile seizure. materials & methods:   in this case-control study, 43 children with simple febrile seizure (case group) were compared with 43 febrile children without seizure (control group) in terms of serum glutathione peroxidase level. serum glutathione peroxidase levels were measured by elisa method. the resu...

introduction : pemphigus comprises a group of diseases characterized by cutaneous and mucosal blistering. pemphigus vulgaris (pv) is the most common and important variant. recent reports have revealed the relatively high incidence of pv in iran. the onset or aggravation of many human diseases is attributed to oxidative stress and it has been suggested as one of the several factors responsible f...

results theophylline-treated rats showed mda level elevation and gpx activity reduction. quercetin treatment improved heart conditions and resulted in a significant reduction in mda levels and elevation in gpx activity. moreover, co-administration of quercetin and theophylline increased the heart weight significantly. furthermore, histophatological study showed no changes in the treated groups....

background: in fertile women, glycodelin and glutathione peroxidase 3 (gpx3) genes expression rises during the luteal phase, with a peak occurring during the implantation window. the expression of these genes decreases in women with myomas. to determine whether myomectomy would reverse glycodelin and gpx3 expression, we evaluated the transcript levels of these genes in the endometrium of patien...

conclusions se supplementation can increase plasma se concentration and rbc gsh-pxs activity in patients with different stages of ckd. background plasma selenium (se) concentration and glutathione peroxidase (gsh-pxs) enzyme activity of the patients with chronic kidney disease (ckd) are usually lower than healthy individuals; however, the effect of se supplementation on the gsh-pxs activity in ...

one of the major classes of ionotropic glutamate receptors is the class of n-methyl-d-aspartate receptors (nmdars). receptor activation recruits, via calcium signal transduction mechanisms which play important roles in oxidative metabolism, mitochondrial free radical production and occurrence of other mitochondrial factors which potentially contribute to excitotoxicity and neuronal death. in...

three levels of lysine (90, 100 and 110% of ross requirement) and of pyridoxine (3, 6 and 9 mg kg-1) were used in a 3 × 3 factorial experiment to investigate the growth and blood antioxidant ability of broilers under high ambient temperature. none of the dietary supplements affected the weight gain during the starter and grower periods. although no significant differences were detected between ...

The glutathione peroxidase-glutathione reductase system, an alternative pathway for metabolic utilization of H2O2 [Chance, Sies & Boveris (1979) Physiol. Rev. 59, 527-605], was investigated in Trypanosoma cruzi, an organism lacking catalase and deficient in peroxidase [Boveris & Stoppani (1977) Experientia 33, 1306-1308]. The presence of glutathione (4.9 +/- 0.7 nmol of reduced glutathione/10(8...