cystatin c is a 13 kd basic protein that is a member of the cystatin superfamily of cysteine protease inhibitors. the cystatin c gene seems to be a house keeping gene, which is compatible with a stable production rate of cystatin c by most cells. this protein is freely filtered through the glomerulus and almost completely reabsorbed and catabolized by proximal tubular cells. because of these ch...

background assessment of glomerular filtration rate (gfr) by common creatinine-based methods is potentially inaccurate in patients with cirrhosis. cirrhotic patients have several underlying conditions that contribute to falsely low serum creatinine concentrations, even in the presence of moderate to severe renal impairment. therefore creatinine-based methods usually overestimate true gfr in the...

Background: Guidelines recommend estimating glomerular filtration rate (GFR) using creatinine-based equations (CBE).

• An accurate assessment of the glomerular filtration rate (GFR) should be undertaken in all potential donors. The benefit of obtaining a directly measured GFR (thought to be more accurate) over an estimated GFR, has not been proven in live donors (refer to CARI guidelines titled ‘Use of estimated glomerular filtration rate to assess level of kidney function’ and ‘Direct measurement of glomerul...

Single glomerulus filtration rate in Eptatretus stouti averaged 20.3+/-2.13 (S.E.M.) nl min(-1). Single glomerulus glomerular filtration rate (GFR) could be correlated with arterial pressure when arterial pressure exceeded about 4 cm H2O. Glomerular filtration was affected by postglomerular resistance brought about by alteration of the volume of urinary spaces. Filtration undoubtedly plays a ro...

Training alterations in elite cyclists may cause transient changes in glomerular filtration rate. To these authors' knowledge, no biochemical investigation of chronic renal function in athletes during a training cycle exists. The purpose of the present archival study was to evaluate the effects of training on homeostatic renal function, evaluated predicted glomerular filtration rate (GFR). Eigh...

We designed a chemical method for measurement of iohexol concentrations (4) and characterized its pharmacokinetics in man in relation to a number of other contrast media (5, 6). We found that is indeed a suitable marker for glomerular filtration rate (GFR): after intravenous injection, it is quantitatively recovered in the urine; the elimination occurs by glomerular filtration, with no signs of...

Introduction: We try to explore the compensatory capacity of living-related donor’s remnant kidney and recipient’s transplanted in terms glomerular filtration rate (GFR).