background : gestational trophoblastic neoplasia (gtn) refers to malignant lesions that arise from abnormal proliferation of placental trophoblast. even in its metastatic forms gtn is curable with a cure rate of 90-100 %. currently, methotrexate with or without folic acid, andactinomycin d is recommended for low risk gtn. the aim of this study is to compare the efficacy of methotrexate and acti...

( Obstet Gynecol . 2021;137:355–370) Gestational trophoblastic disease (GTD) refers to rare processes originating from the placenta that require timely and appropriate management. GTD includes partial or complete hydatidiform moles (HM), as well severe gestational neoplasia (GTN) related tumors. Obstetrician-gynecologists are more likely be involved in care of women with HM who have unclear dia...

Gestational trophoblastic disease (GTD) is a rare but curable disease. Recent improvements in diagnosis and molecular biology have resulted in changes in staging and treatment. These guidelines provide evidence-based recommendation on how to manage GTD.

Introduction: Gestational trophoblastic disease (GTD) consists of group of disorders having pathology of abnormal trophoblastic proliferation ranging from hydatidiform mole to gestational trophoblastic neoplasia. Based on differences in morphology, histopathology, karyotype and clinical features, hydatidiform mole can be categorized into partial and complete moles. Molar pregnancy incidence var...

Gestational trophoblastic neoplasia (GTN) is highly chemosensitive and has a high cure rate. Since the introduction of chemotherapy, reliable measurement of human chorionic gonadotropin (hCG) levels, and individualised risk-based therapy into the management of GTN, almost all low-risk and more than 80 % of high-risk GTN cases are curable. However, approximately 25 % of high-risk GTN developed r...

Background Gestational trophoblastic disease (GTD) defines a heterogenenous group of interrelated lesions that arise from the trophoblastic epithelium of the placenta. There are several histologically distinct types of GTD: hydatiform mole (complete or partial), persistant/invasive gestational trophoblastic neoplasia (GTN), choriocarcinoma and placenta site trophoblastic tumors. The aim of this...

Epithelioid trophoblastic tumor (ETT) is a very rare variant of gestational trophoblastic disease (GTD) which arises in reproductive age women with prior gestational history. Although abnormal vaginal bleeding is the most common symptom of ETT, there are no reported pathognomonic symptoms of ETT because of its rarity. ETT is similar to placental site trophoblastic tumor in terms of its slow gro...

It is universally recognized that an accurate and precise staging and classification system for gestational trophoblastic neoplasia (GTN) is essential to enable clinicians to assess the prognosis or the risk of patients, to individualize and to optimize their treatment. There have been a variety of staging and classification systems developed by different centres and some are still being used. ...

BACKGROUND Gestational Trophoblastic Disease (GTD) is a heterogeneous group of diseases that includes partial and complete hydatidiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumour. The incidence of GTD varies in different parts of the world. The malignant potential of this disease is higher in South East Asia in comparison to western countries. Objectives of stu...