نتایج جستجو برای: gephyrotoxin
تعداد نتایج: 12 فیلتر نتایج به سال:
The tricyclic skeleton of the gephyrotoxin amphibian alkaloids was synthesized via an enantioselective serial sequence involving nine discrete steps that furnished Kishi’s intermediate 5 in 22% overall yield. This efficient and expeditious synthetic approach exploits the inherent stereochemistry of a (1R)-2-tropinone derivative for the construction of the core cis-2,5disubstituted pyrrolidine r...
(-)-gephyrotoxin-223 was formally synthesized from chiral synthon 1 which has been chemoenzymatically synthesized in the presence of candida antartica lipase.
Three different types of modem NMR techniques have been used to obtain a complete proton and carbon13 assignment of the alkaloid gephyrotoxin. In addition to the two-dimensional phase-sensitive homoand heteronuclear shift correlation methods, use of the recently proposed one-dimensional homonuclear Hartmann-Hahn difference experiment was crucial for obtaining the required long-range connectivit...
(-)-Gephyrotoxin-223 was formally synthesized from chiral synthon 1 which has been chemoenzymatically synthesized in the presence of Candida Antartica lipase.
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