Key-words Disease name and synonymes Excluded diseases Diagnostic criteria / definition Differential diagnosis Frequency Clinical description Management including treatment Etiology Diagnostic methods Genetic counselling Unresolved questions References Abstract Lennox-Gastaut syndrome (LGS) belongs to the group of severe childhood epileptic encephalopathies. This disorder is defined as a crypto...

objective the lennox-gastaut syndrome (lgs), one of the most difficult epilepsy syndromes to treat, is characterized by a triad of intractable seizures of various types, a slow (< 2.5-hertz) spike-wave pattern in eeg and mental retardation. the aim of this study was to evaluate the efficacy and safety of lamotrigine as add-on therapy in intractable epilepsy of children with lgs. materials & met...

objective the lennox-gastaut syndrome (lgs: the triad of intractable seizures of various types, a slow spike-wave pattern in eeg and mental retardation) is one of the most difficult epilepsy syndromes to treat. the aim of this study was to evaluate the efficacy and safety of zonisamide (zns) as add-on therapy in seizures of children with lgs. materials & methods in a quasi- experimental study, ...

Lennox-Gastaut syndrome (LGS) is a rare but debilitating pediatric epileptic encephalopathy characterized by multiple intractable seizure types. Treatment of LGS is challenging because of the small number of antiepileptic drugs (AEDs) which are effective for this syndrome, as well as the need for polytherapy in the majority of patients. This review focuses on the treatment of LGS with rufinamid...

Focal brain lesions may be associated with the atypical form of Lennox-Gastaut syndrome (LGS). We describe a drug resistant LGS patient with daily seizures and a left parietal dysembryoplastic neuroepithelial tumour. Pre-surgical evaluation showed, in addition to diffuse paroxysmal EEG discharges associated with atonic and tonic axial seizures, lateralizing EEG and clinical signs pointing to le...

Lennox-Gastaut syndrome (LGS) is a severe epileptic encephalopathy. Few current treatment options are effective in improving seizure control. This paper reviews the available treatments of LGS and discusses a new option in Canada, rufinamide. It is a wide spectrum anticonvulsant, approved in a number of countries for the treatment of LGS. In a randomized controlled trial in the LGS population, ...

Vagus nerve stimulation (VNS) is a new therapeutic option for refractory epilepsy. We report a patient with Lennox-Gastaut-Syndrome (LGS) and a severe impairment of heart rate variability (HRV), we could demonstrate in our patient that HRV was improved by VNS.

PURPOSE To describe the characteristics and frequency of ophthalmologic findings in patients with Lennox-Gastaut syndrome (LGS). METHODS The medical records of patients diagnosed with LGS at Seoul National University Children's Hospital from January 2004 to August 2014 were retrospectively reviewed. The records of 34 patients (mean age ± standard deviation, 2.66 ± 3.51 years; male, 58.8%) wer...

&#x0D; Lennox-Gastaut syndrome (LGS) is a form of severe epileptic encephalopathy in children. LGS with encephalomalacia cysts rare We report six-year-old mentally retarded boy who was referred for an intractable seizure. Seizures were tonic, atonic, and dialeptic frequency. EEG showed generalized SSW discharges 1.5-2 Hz, polyspikes, burst suppression typical LGS. Head MRI cyst the right subcor...

PURPOSE Lennox-Gastaut syndrome (LGS) is a devastating childhood-onset epilepsy syndrome. The cause is unknown in 25% of cases. Little has been described about the specific clinical or electroencephalography (EEG) features of LGS of unknown or genetic cause (LGS(u)). The Epilepsy Phenome/Genome Project (EPGP) aims to characterize LGS(u) by phenotypic analysis of patients with LGS(u) and their p...