Essential fatty acids (EFAs) can be defined by classic definition, which defines EFAs as the fatty acids that are required for proper functioning of cells, but the body cannot synthesize them and, therefore, must be supplied by diet. According to this definition, there are only two EFAs: linolenic acid (LA, C18:2, n-6) and alpha-linolenic acid (ALA, C18:3, n-3). The functional definition of EFA...

85. Arnold, L. E., Kleykamp, D., Votolato, N. A., Taylor, W. A., Kontras, S. B., and Tobin, K. Gamma-linolenic acid for attention-deficit hyperactivity disorder: placebo-controlled comparison to D-amphetamine. Biol.Psychiatry 1-151989;25(2):222-228. View urgess, J. R. other disruptive behaviors. Lipids 2003;38(10):100786. Stevens, L., Zhang, W., Peck, L., Kuczek, T., Grevstad, N., Mahon, A., Ze...

OBJECTIVE To explore the separate and combined effects of simvastatin and a low-saturated diet rich in alpha-linolenic acid on serum fatty acids. METHODS AND RESULTS 120 hypercholesterolemic men were randomly allocated to a habitual diet or dietary treatment group and to receive, in random order, simvastatin 20 mg/d or placebo, each for 12 weeks, in a double-blind manner. Dietary treatment de...

The serum concentration of lipids and composition of fatty acids after overnight fasting were studied in 18 patients with rheumatoid arthritis treated for 12 weeks with either 20 ml of evening primrose oil containing 9% of gamma-linolenic acid or olive oil. The serum concentrations of oleic acid, eicosapentaenoic acid, and apolipoprotein B decreased and those of linoleic acid, gamma-linolenic a...

Introduction Gamma-linolenic acid (GLA) is an important conditionally essential fatty acid (EFA). GLA is an omega-6 polyunsaturated fatty acid (PUFA). The fatty acid molecule is comprised of 18 carbon atoms with three double bonds. It is also known as 18:3n-6; 6,9,12-octadecatrienoic acid; cis-6, cis-9, cis-12octadecatrienoic acid; and gamolenic acid. GLA is found naturally in the fatty acid fr...

The oxidation rates of lauric, myristic, palmitic, stearic, oleic, alpha-linolenic, linoleic, kappa-linolenic, dihomo-gamma-linolenic and arachidonic acids were studied by use of a radioisotope tracer technique in weanling rats at rest in a metabolism chamber over 24 h. Of the saturated fatty acids, lauric acid (12:0) was the most efficient energy substrate: the longer the chain length of the s...

Human or rat microsomal 5 alpha-reductase activity, as measured by enzymic conversion of testosterone into 5 alpha-dihydrotestosterone or by binding of a competitive inhibitor, [3H]17 beta-NN-diethulcarbamoyl-4-methyl-4-aza-5 alpha-androstan-3-one ([3H]4-MA) to the reductase, is inhibited by low concentrations (less than 10 microM) of certain polyunsaturated fatty acids. The relative inhibitory...

Reactive oxygen species (ROS) are elevated by metabolic changes in diabetes, including autoxidation and increased advanced glycation. Endogenous protection by the glutathione redox cycle is also compromised by the competing NADPH requirement of elevated polyol pathway flux. Antioxidant treatment strategies prevent or reverse nerve conduction velocity (NCV) deficits in diabetic rats. These inclu...