different examination have shown that rheumatoid factor is not responsible for false positive reaction (f.p.r.) in cr. neoformanse’s free capsular antigen latex agglutination test, whereas high levels of iron in sera of patients with rheumatoid arthritis as well as other sera was responsible not only for this f.p.r. , but also had an important role in the production of f.p.r. in many slide late...

Prenatal screening is often misconstrued by patients as screening for trisomy 21 alone; however, other chromosomal anomalies are often detected. This study aimed to systematically review the literature and use diagnostic meta-analysis to derive pooled detection and false positive rates for aneuploidies other than trisomy 21 with different prenatal screening tests. Non-invasive prenatal testing ...

Background The geno2pheno algorithm (g2p) can give dichotomous tropism based on a selectable “false positive rate” (FPR), reflecting the proportion of individuals inappropriately called “non-R5” and falsely excluded from taking CCR5 antagonists. The effect of replicate genotype measures and different FPR values remains controversial. Here we characterize different FPR “cut-points” in predicting...

N=number of women having triple test; p=prevalence of Down's syndrome; p*N=total number of fetuses with Down's syndrome; DR=detection rate; FPR=false positive rate; p*N*DR*AR=number of women with true positive results who have amniocentesis; (1-p)*N*FPR*AR=number of women with false positive results who have amniocentesis; p*N*DR*AR=number having an abortion (all positive amniocentesis results)...

A small number of studies have investigated breast cancer (BC) risk among women with a history of false-positive recall (FPR) in BC screening, but none of them has used time-to-event analysis while at the same time quantifying the effect of false-negative diagnostic assessment (FNDA). FNDA occurs when screening detects BC, but this BC is missed on diagnostic assessment (DA). As a result of FNDA...

Mining of gene expression data to identify genes associated with patient survival is an ongoing problem in cancer prognostic studies using microarrays in order to use such genes to achieve more accurate prognoses. The least absolute shrinkage and selection operator (lasso) is often used for gene selection and parameter estimation in high-dimensional microarray data. The lasso shrinks some of th...

Phishing emails risk increases progressively, which pose a real threat to users of computers, organizations and lead to significant financial losses. Fighting zero day phishing emails using content based server side classifiers is considered as the best method to detect such attacks. This technique which is based on machine learning algorithms is trained by the set of phishing email features an...

Methods Population-based and “deep” V3-loop sequencing were performed in 53 MVC recipients in the MERIT, MOTIVATE and A4001029 studies who spontaneously changed tropism readout by the original Trofile assay between screening and baseline (~4-8 weeks) and 72 randomly sampled patients who did not change. Tropism was inferred by “geno2pheno” with previously defined cutoffs: 2% X4 prevalence with a...

BACKGROUND Newborn screening (NBS) for the classic forms of congenital adrenal hyperplasia (CAH) is mandated in all states in the United States. Compared with other NBS disorders, the false-positive rate (FPR) of CAH screening remains high and has not been significantly improved by adjusting 17α-hydroxyprogesterone cutoff values for birth weight and/or gestational age. Minnesota was the first s...

OBJECTIVE The study aims to determine the performance of a five (5) serum marker plus ultrasound screening protocol for T21, T18 and T13. METHOD Specimens from 331 unaffected, 34 T21, 19 T18 and 8 T13 cases were analyzed for free Beta human chorionic gonadotropin, pregnancy-associated plasma protein A, alpha-fetoprotein, placental growth factor and dimeric inhibin A. Gaussian distributions of...