Flavokawain A (FKA) is the predominant chalcone identified from the kava plant. We have previously shown that FKA preferentially inhibits the growth of p53 defective bladder cancer cell lines. Here, we examined whether FKA could inhibit bladder cancer development and progression in vivo in the UPII-SV40T transgenic model that resembles human urothelial cell carcinoma (UCC) with defects in the p...

Flavokawain A (FKA), a major chalcone in the Kava plant, has recently demonstrated promising anti-cancer activities. A systematic evaluation of FKA's safety profile has not been reported before. In this study, male FVB/N mice were fed with an AIN-76A diet or AIN-76A diet supplemented with 0.6% (6 g/kg food) FKA or 0.6% commercial kava root extract (KRE) for three weeks. Dietary feeding of FKA d...

HER2/neu positive breast tumors predict a high mortality and comprise 25%-30% of breast cancer. We have shown that Flavokawain A (FKA) preferentially reduces the viabilities of HER2-overexpressing breast cancer cell lines (i.e., SKBR3 and MCF7/HER2) versus those with less HER2 expression (i.e., MCF7 and MDA-MB-468). FKA at cytotoxic concentrations to breast cancer cell lines also has a minimal ...

INTRODUCTION The kava-kava plant (Piper methsyticum) is traditionally known as the pacific elixir by the pacific islanders for its role in a wide range of biological activities. The extract of the roots of this plant contains a variety of interesting molecules including Flavokawain A and this molecule is known to have anti-cancer properties. Breast cancer is still one of the leading diagnosed c...

HER2/neu positive breast tumors predict a high mortality and comprise 25-30% of breast cancer. We have shown that Flavokawain A (FKA) preferentially reduces the viabilities of HER2 overexpressing breast cancer cell lines (i.e. SKBR3 and MCF7/HER2) versus those with less HER2 expression (i.e. MCF7 and MDA-MB-468). FKA at cytotoxic concentrations to breast cancer cell lines also has minimal effec...

S phase kinase-associated protein 2 (Skp2) has been shown to be required for spontaneous tumor development that occurs in the retinoblastoma protein (pRb) deficient mice. Here we have demonstrated that flavokawain A (FKA), a novel chalcone from the kava plant, selectively inhibited the growth of pRb deficient cell lines and resulted in a proteasome-dependent and ubiquitination-mediated Skp2 deg...

Research on how business model innovation (BMI) in international markets affects performance continues to proliferate. However, existing research is sparse primary predictors of this relationship. Drawing upon knowledge creation theory, article investigates a serial mediation that supports the role indirect effects foreign acquisition (FKA) via orientation (IO) and BMI performance. Utilizing ti...

We use electroabsorption (EA) spectroscopy to measure the exciton binding energy (EB), electron−hole reduced effective mass (μ), and one-electron band gap (Eg) at the fundamental absorption edge of the hybrid organic− inorganic perovskite CH3NH3PbI3 in its tetragonal phase at 300 K. By studying the second-harmonic EA spectra at the fundamental absorption edge we establish that the roomtemperatu...

Introduction: Bracing is an accepted part of operative treatment, however; the effectiveness of bracing is controversial. We sought evidences for the effect of Thoracolumbosacral Orthosis (TLSO) on spine proximal to the fusion site in patients treated for unstable thoracolumbar junction (TLJ) burst fractures. Materials and Methods: Fifty adult patients with unstable TLJ burst fractures are pros...

The diagnosis of pigmented actinic keratosis (PAK) is often challenging because of overlapping features with lentigo maligna. OBJECTIVE To investigate dermoscopic patterns of PAK according to their different evolutionary stages, and to correlate the pattern with clinical characteristics of the patients. METHODS Descriptive and analytical study of 232 PAK. Dermoscopic patterns were divided i...