نتایج جستجو برای: f (ab)2

تعداد نتایج: 305940  

Journal: :The Journal of Experimental Medicine 1981
C A Bona E Heber-Katz W E Paul

BALB/c mice immunized multiple times with ABPC48 (A48 or Ab1), a BALB/c bacterial levan (BL)-binding myeloma proteins, produce anti-Ab1 antibodies (Ab2). Immunization with only tow doses of AB1 often leads to the production of anti (antiA48) (Ab3) as does immunization with hemocyanin conjugates of Ab2. Finally, immunization with hemocyanin conjugates of Abf3 leads to the production of anti- (an...

Journal: :Protein engineering, design & selection : PEDS 2010
A Mader R Kunert

Anti-idiotypic antibodies could represent an alternative vaccination approach in human therapy. The anti-idiotypic antibody Ab2/3H6 was generated in mouse and is directed against the human monoclonal antibody 2F5, which broadly and potently neutralizes primary HIV-1 isolates. Ab2/3H6 is able to mimic the antigen recognition site of 2F5 making it a putative candidate for HIV-1 vaccine purposes. ...

Journal: :Experimental oncology 2013
V A Ustinov V A Matveeva M A Kostyanko A N Glushkov

AIM To evaluate the production of antibodies against benzo[a]pyrene (BP) (Ab1) and corresponding antiidiotypic antibodies (Ab2) in mice after immunization with BP-protein conjugate and in lung cancer patients. MATERIALS AND METHODS The Ab1 and Ab2 levels were measured by non-competitive ELISA in blood serum of 10 mice immunized with BP-protein conjugate, and in blood serum of 288 healthy pers...

2011
Renate Kunert Alexander Mader

Background and aims Anti-idiotypic antibodies (Abs) represent an alternative vaccination approach in human therapy. This approach is based on the idiotype (Id) network theory postulated by Jerne describing the Ab (Ab1) – anti-idiotypic Ab (Ab2) – anti-anti-idiotypic Ab (Ab3) cascade stimulation. Specific anti-Id Abs serve as an “internal image” of the target antigen and can be used to induce Ab...

Journal: :Acta medica Okayama 2002
Michio Hirai Motowo Mizuno Yoshiko Morisue Masao Yoshioka Morizou Shimada Junichirou Nasu Hiroyuki Okada Hiroyuki Shimomura Kazuhide Yamamoto Takao Tsuji

Anti-idiotype antibodies (Ab2) play an important role in the homeostasis of immune responses and are related to the development and the disease activity of certain autoimmune diseases. The asialoglycoprotein receptor (ASGPR) is considered one of the target antigens in the pathogenesis of autoimmune chronic active hepatitis (AIH). We previously developed a mouse monoclonal antibody (clone 8D7) w...

Journal: :Clinical and diagnostic laboratory immunology 2000
A R Souza J L Gesztesi G M del Negro G Benard J Sato M V Santos T B Abrahão J D Lopes

Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Latin America. Patients with PCM show a wide spectrum of clinical and pathological manifestations depending on both host and pathogen factors. Two clinical forms of the disease are recognized: the acute or juvenile form and the chronic or adult form. The major antigenic component of the parasite is a glycoprotein of 43 kDa (...

Journal: :The Journal of Experimental Medicine 1994
Y Gruel E Brojer D J Nugent T J Kunicki

A patient (OG) with Glanzmann thrombasthenia became refractory to platelet transfusion after the production of an immunoglobulin G (IgG) isoantibody (Ab1) specific for the integrin subunit beta 3. To determine the frequency at which the OG idiotype is found in the general population and in immune-mediated disease states, we developed a rabbit polyclonal antibody (Ab2) specific for affinity-puri...

2015
Md Shahaduzzaman Kevin Nash Charles Hudson Masroor Sharif Bethany Grimmig Xiaoyang Lin Ge Bai Hui Liu Kenneth E. Ugen Chuanhai Cao Paula C. Bickford

The protein α-synuclein (α-Syn) has a central role in the pathogenesis of Parkinson's disease (PD) and immunotherapeutic approaches targeting this molecule have shown promising results. In this study, novel antibodies were generated against specific peptides from full length human α-Syn and evaluated for effectiveness in ameliorating α-Syn-induced cell death and behavioral deficits in an AAV-α-...

2016
Kwo-hsiung Young Benjamin Chao

The surface microstructure of an activated Si-containing AB2 metal hydride (MH) alloy was investigated by transmission electron microscopy (TEM) and X-ray energy dispersive spectroscopy (EDS). Regions of the main AB2 and the secondary TiNi (B2 structure) phases directly underneath the surface Zr oxide/hydroxide layers are considered electrochemically inactive. The surface of AB2 is covered, on ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1995
J Fagerberg M Steinitz H Wigzell P Askelöf H Mellstedt

Induction of immunity against antigens expressed on tumor cells might prevent or delay recurrence of the disease. Six patients operated on for colorectal carcinoma were immunized with human monoclonal anti-idiotypic antibodies (h-Ab2) against the mouse 17-1A anti-colon carcinoma antibody, mimicking a nominal antigen (GA733-2). All patients developed a long-lasting T-cell immunity against the ex...

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