Oxidative stress in cardiac fibroblasts (CFs) promotes transformation to myofibroblasts and collagen synthesis leading to myocardial fibrosis, a precursor to heart failure (HF). NADPH oxidase 4 (Nox4) is a major source of cardiac reactive oxygen species (ROS); however, mechanisms of Nox4 regulation are unclear. β-arrestins are scaffold proteins that signal in G-protein-dependent and -independen...

1 Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia 2 Departments of Neurology and Pediatrics, The University of California and the Benioff Children’s Hospital, CA, 94158, USA 3 Departments of Pediatrics and Neurosurgery, Radiology and Biomedical Imaging, The University of California Children’s Hospital, CA 94143, USA 4 Departments of Paediatrics and Neurosurge...

background: considering differences in head size and shape of different equine breeds, biometric parameters can be an attribute to a particular race. objectives: the purpose of the present paper is to give a numerical definition of morphological characteristics of head region of the darehshori horse. methods: twenty mature darehshori horses were studied biometrically. the ear length, ears dista...

800x600 to analyse the effect of congenital unilateral ptosis on the ocular higher order aberrations (hoa) and to compare these eyes with normal fellow eyes this study has been performed. in this observational comparative case series, 16 eyes of 16 patients less than 15 years old with congenital unilateral upper eyelid ptosis were included. corrected distance visual acuity (cdva), corneal topog...

Our ability to perceive many aspects of the human face is so acute that some would propose that we possess specialised face-processing mechanisms. One example of this exquisite performance is our ability to discriminate differences in the lateral separation of the eyes in pairs of otherwise identical facesösee Kemp et al (1990, Perception 19 531 ^ 543). However, we have found that our ability t...

purpose : the objective of this study was to evaluate the outcome of acrysof toric intraocular lenses (iols) implantation in cataract surgery for the correction of regular corneal astigmatism. methods : twenty eyes of 16 patients with cataract and regular corneal astigmatism of 1.00-4.00 diopter (d) underwent surgery. depending on the amount of corneal astigmatism, an acrysof toric iol of type ...

AIMS To assess the long term functional and structural outcomes of premature babies who received diode laser photocoagulation for threshold retinopathy of prematurity (ROP). METHODS 25 patients (43 eyes) treated with laser were recalled for assessment at a mean follow up of 11 years. A further seven patients (14 eyes) with subthreshold ROP, which had regressed spontaneously without laser trea...

Does an assimilative illusion like the Delboeuf illusion occur in the human face? We investigated factors that might influence the perceived size of the eyes in a realistic face. Experiment 1 manipulated the position of the eyebrows (high or low), the presence/absence of eye shadow, and the viewing distance (0.6 m or 5 m), then measured the perceived eye size using a psychophysical method. The ...