PURPOSE To summarize various topics and the cutting edge approaches to refine XFS pathogenesis that were discussed at the 21st annual Glaucoma Foundation Think Tank meeting in New York City, Sept. 19-20, 2014. METHODS The highlights of three categories of talks on cutting edge research in the field were summarized. RESULTS Exfoliation syndrome (XFS) is a systemic disorder with a substantial...

Pseudo exfoliation syndrome (XFS) is an age-related, generalized disorder of the extracellular matrix characterized by the production and progressive accumulation of an abnormal fibrillar extracellular material in many ocular tissues and is the most common identifiable cause of openangle glaucoma worldwide. Exfoliation syndrome plays an etiologic role in open-angle glaucoma, angle-closure glauc...

purpose: to compare body mass index (bmi) in patients with exfoliation syndrome (xfs) and a matched control group. methods: in a cross-sectional study, 84 patients with xfs (xfs group) and 84 persons without xfs (control group) were matched for sex and age and selected sequentially. bmi was compared in the two groups. patients with xfs with or without glaucoma and other complications were inclu...

PURPOSE To investigate possible genetic associations of matrix metalloproteinase-1 (MMP1) and MMP3 gene polymorphisms with exfoliation syndrome (XFS) with (XFS/+G) and without (XFS/-G) glaucoma in a cohort of Greek patients. METHODS A total of 182 unrelated Greek patients with XFS, including 92 patients with XFS/+G, and 214 unrelated age- and gender-matched controls were enrolled in the study...

Exfoliation syndrome (XFS) is an age-related disorder of the extracellular matrix that leads the production of abnormal fibrillar material that leads to elevated intraocular pressure and a relatively severe glaucoma. Exfoliation material is deposited in numerous ocular tissues and extraocular organs. XFS is associated with ocular ischemia, cerebrovascular disease, neurodegenerative disease and ...

PURPOSE To evaluate the association profiles of the lysyl oxidase-like 1 (LOXL1) gene polymorphisms with exfoliation syndrome in a Chinese population. METHODS Fifty unrelated patients with exfoliation syndrome and 125 control subjects were included. Genotypes of the three single nucleotide polymorphisms (SNPs) of LOXL1 (rs1048661, rs3825942, and rs2165241) were analyzed by direct sequencing, ...

Purpose: To assess the frequency of exfoliation syndrome (XFS) in Jordanian patients scheduled for cataract surgery. Methods: A retrospective chart review was conducted on 445 consecutive patients who had cataract surgery at our center over one year. Data collected included age, sex, presence of XFS, predominant type of lens opacity and intraocular pressure (IOP). Results: Mean age of the total...

Purpose To estimate the frequency of exfoliation syndrome (XFS) and its association with ocular diseases in Northern Nigeria. Materials and methods Consecutive patients who presented to the outpatient department of ECWA Eye Hospital Kano from February 2015 to May 2015 were included in the study. Each patient had a complete ophthalmic examination. The anterior segment examination included tono...

purpose : to evaluate the retinal nerve fiber layer (rnfl) and central corneal thickness (cct) in patients with exfoliation syndrome (xfs) methods : in this comparative case series we measures rnfl thickness and cct 30 patients with xfs and 30 age and sex matched healthy subjects who met the inclusion criteria. results : average rnfl in xfs group were significantly thinner than controls (94.36±...

PURPOSE To investigate the lysyl oxidase-like 1 (LOXL1) gene for single nucleotide polymorphism (SNP) variations in Japanese patients with exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) and to examine the phenotypes of the patients with these variations. METHODS Fifty-six unrelated Japanese patients with XFS, including 36 patients with XFG, were studied. Genomic DNA was extracted f...