evliya chelebi (1611-1682), was an ethnically ottoman explorer who travelled through the territory of the ottoman empire and neighboring lands over a period of forty years, recording his commentary in a travelogue called the seyahatname. during his lifetime, evliya chelebi made three journeys to safavid iran: the first in 1646 to azerbaijan and caucasus, the second in 1647 which was a very shor...

Değirmenlerin kökeni, Eski Çağ uygarlıklarının temel besin maddelerinden olan tahılları öğütmek için kullandıkları ilk öğütme taşlarına dayanmaktadır. Uygarlıklar gelişimlerini ilerlettikçe canlı varlıklara dayanan enerji kaynaklarının yerini su ve rüzgâr gibi doğal türleri almaya başladı. En eski üretim merkezlerinden değirmenler Osmanlı medeniyetinin sosyal kültürel anlamda gelişmesine de kat...

1 Department of Otolaryngology Head and Neck Surgery, Evliya Celebi Training and Research Hospital, Dumlupinar University, 43270 Kutahya, Turkey 2Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Osmangazi University, Meselik Campus, 26480 Eskisehir, Turkey 3 Department of Otolaryngology Head and Neck Surgery, Turgut Ozal Medical Center, Inonu University, 44280 Malatya, T...

Milk thistle (Silybum marianum) extracts are widely used as a complementary and alternative treatment of various hepatic conditions and a host of other diseases/disorders. The active constituents ofmilk thistle supplements are believed to be the flavonolignans contained within the extracts. In vitro studies have suggested that some milk thistle components may significantly inhibit specific cyto...

Fragile X syndrome is due to mutation of the FMR1 gene. The most common mutation is an expansion of a CGG repeat in the 50 UTR that triggers dense DNA methylation and formation of a heterochromatin-like structure which lead to transcriptional silencing. In vitro experiments have identified several transcription factors, including Sp1, Nrf-1 and USF1/2, as potential regulators of normal FMR1 pro...

Background. Sport lodges are institutions that are responsible for providing athletes with accommodation, food and training. Sport lodges had the same tasks as today's sports clubs and played a vital role in the institutionalization and development of sports within the borders of the Ottoman Empire. Evliya Çelebi is a prominent 17th century traveler. During his lifetime, he traveled throughout ...

Presystemic interactions with gut microbiota might play important roles in the holistic action of herbal medicines in their traditional oral applications. However, research interests usually focus on biologic activities of the in vivo available herb-derived components and their exposure in circulation. In this study, we illustrated the importance of studying the presystemic interplay with gut m...

Step 1: Indication Development and Literature Review.................................................................1608 Step 2: Expert Panel Rating.................................1609 Step 3: Panel Meeting..........................................1609 Step 4: Rating Tabulation ....................................1610 Interpretation of Appropriateness Scores .................1610 Appropriaten...