The microbial transformation of oral contraceptive norethisterone (1) by Cephalosporium aphidicola afforded an oxidized metabolite, 17α-ethynylestradiol (2), while the microbial transformation of 2 by Cunninghamella elegans yielded several metabolites, 19-nor-17α-pregna-1,3,5 (10)trien-20-yne-3,4,17β -triol (3), 19-nor-17α-pregna-1,3,5 (10)-trien-20-yne-3,7α ,17β -triol (4), 19nor-17α-pregna-1,...

Herewith please find corrected structures for Figure 8 in our paper published in Sensors in 2010 [1]. The structure for 17α-ethynylestradiol used for the analysis is shown below: With product number E4876-1G from sigma Aldrich. The corrected structure of naphthalene is below with no double bond in between carbon 2 and 7.

This study aimed to develop sex reversal procedures targeting the embryonic period as tools to study the early steps of sex differentiation in Nile tilapia with XX, XY, and YY sexual genotypes. XX eggs were exposed to masculinizing treatments with androgens (17α-methyltestosterone, 11-ketotestosterone) or aromatase inhibitor (Fadrozole), whereas XY and YY eggs were subjected to feminizing treat...

17α-estradiol (αE2), an endogenous stereoisomer of the hormone 17β-estradiol (E2), is capable binding to estrogen receptors (ER). We aimed mathematically describe, using experimental data, possible interactions between αE2 and sperm ER during process capacitation develop a kinetic model. The goal was compare suggested model with previously published results E2 17α-ethynylestradiol (EE2). HPLC-M...

The occurrence of endocrine disrupting chemicals (EDCs) is a major issue for marine and coastal environments in the proximity urban areas. EDCs Pearl River Delta region well documented but specific data related to Macao unavailable. levels bisphenol-A (BPA), estrone (E1), 17α-estradiol (αE2), 17β-estradiol (E2), estriol (E3), 17α-ethynylestradiol (EE2) were measured sediment samples collected a...

17α-Ethynylestradiol (EE2) has gotten growing concerns due to its widely detected in the environment and high estrogenic potency. However, the knowledge on the photochemical behaviors of EE2 in natural waters is still limited. Herein, the photodegradation and estrogenic potency variation of EE2 induced nitrate were studied using a sunlight simulator consisted by a 300 W medium pressure mercury ...

Emerging contaminants such as 17α-ethynylestradiol (EE2) can be discharged from sewage systems and contaminate water supplies. Paranoá Lake is a strategic reservoir in Brasília (Brazil) that receives treated treatment plants (STPs) has recently become supply. This study monitored EE2 residues different matrices watershed using the ELISA method. monitoring was performed together with local envir...

BACKGROUND & AIMS In cholestatic syndromes, body accumulation of bile acids is thought to cause itching. However, the mechanisms supporting this effect remain elusive. Recently, GPBAR1 (TGR5) a G-protein coupled receptor has been shown to mediate itching caused by intradermal administration of DCA and LCA. 6α-ethyl-3α, 7α-dihydroxy-24-nor-5β-cholan-23-ol (BAR502) is a non-bile acid dual ligand ...