Due to the active role of estrogen receptor α (ERα) in certain breast cancer, finding possible ERα antagonists is important for lowering growth rate ERα-motivated cancer cells. Here, current work was conducted computationally find inhibitors based on use docking methods. The three-dimensional (3D)-ERα structure freely docked with 3D ligands, including milbemycin_A3_5-oxime (MA), Baloxavir marbo...

introduction: the estrogen receptors are potential candidates in prognosis and particularly in predicting hormone response therapy in breast cancer. the aim of this study was to measure erα gene expression due to study of the association between erα expression, age and menopause of iranian women with breast cancer. methods: 21 adenocarcinoma cases with grade 2 and 10 normal samples were screene...

Background: Tooth enamel mineralization is assumed to be a target of endogenous estrogen imbalances. Objective: To evaluate the effect deficiency during amelogenesis on mineral composition dental enamel. Methods: Ten female Wistar Hannover rats were randomly divided into two groups according intervention received: ovariectomy surgery (OVX, experimental) and fictitious (SHAM, control). After 21 ...

Objective(s): Estrogen receptor-alpha (ERα) mediates estrogen action in regulation of different levels of the hypothalamic-pituitary-testis axis. It has a key role in spermatogenesis. Estrogen receptor alpha knock-out (ER koα) male mice were infertile and severe impairment in spermatogenesis and seminiferous tubules was observed. Recently, it has been reported that microRNA (miRNA) mir-100 and ...

Susceptibility to breast cancer is significantly increased in individuals with germ line mutations RECQ1 (also known as RECQL or RECQL1), a gene encoding DNA helicase essential for genome maintenance. We previously reported that expression predicts clinical outcomes sporadic patients stratified by estrogen receptor (ER) status. Here, we utilized an unbiased integrative genomics approach delinea...

Background: The study aimed at evaluating steroid biomarker genes (ERα, PGR, ERβ) and determining the expression level of estrogen-regulated (SCUB2 BCL2) growth factors receptors (HER2 IGFR1) in cancer tissue samples obtained from Iranian patients with breast cancer. Moreover, relationships clinicopathologic aspects tumor response to treatment were studied. Methods: current was conducted on 246...

A set of isoflavononid and flavonoid analogs was prepared evaluated for estrogen receptor α (ERα) ERβ transactivation anti-neuroinflammatory activities. Structure–activity relationship (SAR) study naturally occurring phytoestrogens, their metabolites, related isoflavone revealed the importance C-ring isoflavonoids ER activity selectivity. Docking suggested putative binding modes daidzein 2 dehy...

Estrogen receptor alpha (ERα) is a ligand-activated transcription factor. Upon estrogen stimulation, ERα recruits a number of coregulators, including both coactivators and corepressors, to the estrogen response elements, modulating gene activation or repression. Most coregulator complexes contain histone-modifying enzymes to control ERα target gene expression in an epigenetic manner. In additio...

objective: breast cancer is the most common cancer in iranian women. breast tumors are classified based on the estrogen receptor alpha (erα) expression status into er negative and er positive tumors. er negative tumors tend to have worse prognosis and less likely to respond to endocrine therapy. aberrant methylation of gene promoter is one of the mechanisms for gene silencing in breast tumors. ...