equilibrium-line altitudes (elas) of former glaciers in the zardkuh mountain of the zagros mountain range were reconstructed from glacial-geologic data on former ice limits by using various methods. in the study area various types of glacial landforms such as outwash fans, moraines and well developed glacial cirques are observed. the results suggest that ela were depressed 1433 m below to prese...

Equilibrium-line altitudes (ELAs) of former glaciers in the Zardkuh Mountain of the Zagros Mountain Range were reconstructed from glacial-geologic data on former ice limits by using various methods. In the study area various types of glacial landforms such as outwash fans, moraines and well developed glacial cirques are observed. The results suggest that ELA were depressed 1433 m below to prese...

Elabela (ELA) or Toddler is a recently discovered hormone which is required for normal development of heart and vasculature through activation of apelin receptor (APJ), a G protein-coupled receptor (GPCR), in zebrafish. The present study explores whether the ELA-APJ signaling pathway is functional in the mammalian system. Using reverse-transcription PCR, we found that ELA is restrictedly expres...

Early life adversity (ELA) affects physiological and behavioral development. One key component is the relationship between the developing Hypothalamic-Pituitary-Adrenal (HPA) axis and the Sympathetic Nervous System (SNS). Recent studies suggest a relationship between early life adversity and asymmetry in cortisol (a measure of HPA activation) and salivary alpha-amylase (sAA: a correlate of SNS ...

BACKGROUND Elabela/toddler (ELA) is a critical cardiac developmental peptide that acts through the G-protein-coupled apelin receptor, despite lack of sequence similarity to the established ligand apelin. Our aim was to investigate the receptor pharmacology, expression pattern, and in vivo function of ELA peptides in the adult cardiovascular system, to seek evidence for alteration in pulmonary a...

We examine the validity of two methods for estimating glacier equilibrium-line altitudes (ELAs) from topographic maps. The ELA determined by contour inflection (the kinematic ELA) and the mean elevation of the glacier correlate extremely well with the ELA determined from mass-balance data (observed ELA). However, the range in glacier elevations above sea level is much larger than the variation ...

Enhanced locomotory activity (ELA), such as wandering, is a normal behavior that occurs at the end of the larval stage in lepidopteran (butterflies and moths) insects. Baculovirus infection can also induce ELA in lepidopteran larvae. The belief is that the virus induces this behavior to increase its transmission [Goulson, D. (1997) Oecologia 109, 219-228]. Here we show that a baculovirus-encode...

Early-life adversities (ELA) are associated with subsequent pervasive alterations across a wide range of neurobiological systems and psychosocial factors that contribute to accelerated onset of health problems and diseases. In this article, we provide an integrated perspective on recent developments in research on ELA, based on the articles published in this Special Issue of Psychosomatic Medic...

Early life adversity (ELA) increases the risk for multiple age-related diseases, such as diabetes type 2 and cardiovascular disease. As prevalence is high, ELA poses a major and global public health problem. Immunosenescence, or aging of the immune system, has been proposed to underlie the association between ELA and long-term health consequences. However, it is unclear what drives ELA-associat...

In vitro and ex vivo experiments indicate that elastase-2 (ELA-2), a chymotrypsin-serine protease elastase family member 2A, is an alternative pathway for angiotensin II (Ang II) generation. However, the role played by ELA-2 in vivo is unclear. We examined ELA-2 knockout (ELA-2KO) mice compared to wild-type (WT) mice and determined whether ELA-2 played a role in hemodynamics [arterial pressure ...