Endothelial Nitric Oxide Synthase (eNOS) produces nitric oxide (NO) from L-arginine and is important for the maintenance of cardiovascular homeostasis. Congestive heart failure (CHF) generally results in increased pulmonary blood flow and if untreated leads to pulmonary hypertension and end stage heart failure. We therefore hypothesized that increased pulmonary flow without changes in pres...

Background. Due to the lack of sufficient information about the interactive effects of high intensity intermittent training (HIIT) and blood flow restricted (BFR) exercises on angiogenic variables of skeletal muscle, it seems that integration these training models can influence skeletal muscle angiogenesis in the long term over the individual application of each of these training methods. Obje...

objective: oxidative stress damages cells and brings about the pathogenesis of ischemia/reperfusion injury. this study was carried out to investigate the preconditioning and cardio protective potential effects of crocin and vitamin e by the enos and inos express gene in ischemia/reperfusion in rats. material & methods: male rats were divided into seven groups, namely: sham, control group and ex...

endothelial nitric oxide synthase (enos) produces nitric oxide (no) from l-arginine and is important for the maintenance of cardiovascular homeostasis. congestive heart failure (chf) generally results in increased pulmonary blood flow and if untreated leads to pulmonary hypertension and end stage heart failure. we therefore hypothesized that increased pulmonary flow without changes in pressure ...

Endothelial dysfunction, with impaired bioavailability and/or bioactivity of the vasoprotective molecule, nitric oxide, appears to be a vital step in initiation atherosclerosis. Several studies have shown that dietary nitrate/nitrite can significant benefits on human cardiovascular homeostasis. Although serum nitrite concentrations reach micromolar levels, physiological significance normal tiss...

Aldosterone is traditionally viewed as a hormone regulating electrolyte and blood pressure homeostasis. Recent studies suggest that Aldo can cause microvascular damage, oxidative stress and endothelial dysfunction. However, its exact cellular mechanisms remain obscure. This study was undertaken to examine the effect of Aldo on superoxide production in human umbilical artery endothelial cel...

BackgroundSodium-glucose cotransporter 2 inhibitors (SGLT2i) clinically reduce atherosclerosis and lower blood pressure. However, their impact on endothelial dysfunction in type diabetes (T2D) remains unclear. In this study, we investigated the protective effect underlying mechanism of SGLT2 inhibitor dapagliflozin diabetes.MethodsVascular reactivity was measured to assess vasoprotective a mous...

Endothelial nitric oxide synthase (eNOS) plays a critical role in regulating and maintaining healthy cardiovascular system. The importance of eNOS can be emphasized from the genetic polymorphisms gene, uncoupling dimerization, its numerous signaling regulations. activity on cardiac myocytes, vasculature, central nervous system are discussed. effects sympathetic autonomic (SANS) parasympathetic ...

aldosterone is traditionally viewed as a hormone regulating electrolyte and blood pressure homeostasis. recent studies suggest that aldo can cause microvascular damage, oxidative stress and endothelial dysfunction. however, its exact cellular mechanisms remain obscure. this study was undertaken to examine the effect of aldo on superoxide production in human umbilical artery endothelial cells (h...