introduction: as an inherited neurodegenerative disease, huntington's disease is accompanied with wide neuronal degeneration in neostriatum and neocortex. progress of the disease causes disabling clinical effects on movements, recognition and physiology of the body, and finally results in death. at this stage of knowledge we are, there is no effective therapeutic strategy for diminishing t...

statement of the problem many diseases to be treated by dentists require drug therapy. lack of paying enough attention to principles of drug prescription can lead to problems such as unsuccessful treatment. on the other hand, the most important way to prevent such problems is paying enough attention to prescription of drugs materials and methods in this descriptive study, 260 prescriptions rand...

ingestion of ciprofloxacin can be associated with esophagitis and esophageal ulcer. we report a 46-yearold man with odynophagia and dysphagia following ciprofloxacin ingestion, with a glance on diagnosis and treatment. also, we propose recommendations for prevention of drug-induced esophagitis, according to shape, size, formulation and their etiologic role on esophagitis.

hepatic toxicity is the most serious adverse effect of anti tuberculosis drugs. this study was performed to evaluate efficacy of silymarin as a hepatoprotective herbal agent. in a randomized double blind clinical trial 70 new cases of pulmonary tuberculosis were divided into two groups. the intervention group was assigned to receive silymarin and the control group received placebo. tuberculosis...

adverse effects of antituberculosis agents such as hepatotoxicity may reduce treatment effectiveness, because they significantly contribute to nonadherence and eventually result in treatment failure, relapse or the emergence of drug resistance. garlic is an ancient herbal substance, which its effectiveness on isoniazid and rifampicin-induced hepatic injury in animal models has been demonstrated...

abstract background: the incidence of pregnancy induced hypertension (pih) which is one of the three main causes of maternal-neonatal morbidity and mortality is 5-7%, and prediction of this disorder is very important in maternal and neonatal health. methods: the type of this study is analytical (comparative-prospective) and its purpose is to evaluate the isometric exercise test (let) and roll-o...

objective: tardive dyskinesia (td), is one of the important problems of the patients with schizophrenia. the emergence of these side effects depends on so many factors such as the patients' age and the duration of antipsychotic treatment. by discovering new drugs (atypical), there has been an outstanding decrease in the emergence of these side effects. the present study investigates the symptom...

introduction drug-induced liver injury is a frequent cause of hepatic dysfunction. several drugs have been identified to cause autoimmune hepatitis (aih). environmental chemicals are capable of triggering a certain degree of liver injury. however, toxin induced aih is rare. conclusions chronic (long-term) exposures to dichlorvos can lead to aih. a detailed inquiry of medical history and liver b...

background: hepatotoxicity is a major concern during tuberculosis (tb) drug therapy. its prevalence ranges from 1%-4% in developed countries to 11.5% in developing countries, and is even higher in countries such as india. disease mortality is 5%, but can be prevented by early detection. this study reveals the revalence and outcome of drug-induced hepatitis (dih) in positive sputum tb patients t...

conclusions in conclusion, we have shown that vitamin c administration provides protection against csa-induced injury in rat liver function and may have hepatoprotective role in the patients experiencing csa treatment. background cyclosporine a (csa) is an important immunosuppressive agent; however, its clinical use is limited by several side effects such as hepatotoxicity. vitamin c (ascorbic ...