HLA class II DRB1, DQB1 and DQA1 gene probes were used to study DNA from unrelated French Canadian multiple sclerosis (MS) patients and controls by restriction fragment length polymorphism (RFLP) analysis. An MS-associated and linked series of allele-specific RFLPs or allogenotypes was identified among this relatively homogeneous ethnic group; the allogenotypes include DRw15, DQw6 and a DQA1 al...

The ovine class II major histocompatibility complex mediates specific immune responses to exogenous antigens in sheep. A number of ovine class II loci have been identified, and most of them appear to be polymorphic. In this study we investigated the DQA1 locus of 520 sheep and the DQA2 locus of over 40,000 sheep, finding 12 sequences and 22 sequences, respectively, using DQA1- and DQA2-specific...

BACKGROUND The association between psoriasis and the HLA antigens encoded by the Major Histocompatibility Complex (MHC) genomic region is well known, but the role of the HLA class II region in susceptibility to psoriasis is unclear. OBJECTIVE The purpose of this study is to map the psoriasis-susceptibility locus within the HLA class II region. METHODS Three hundred seventy five unrelated Ja...

شور و داوم اه : ،یبرجت همین قیقحت نیا رد 28 نیماتیو ،نیرمت ،لرتنک هورگ راهچ هب یفداصت روط هب و باختنا قاچ رتخد C یبیکرت و دندش میسقت . نیرمت تدش اب يزاوه 50 ات 70 ،رثکادح بلق نابرض دصرد 3 تدم هب و هتفه رد هسلج 8 هتفه دش ماجنا . هورگ ياه نیماتیو C و صرق یبیکرت 500 یلیم نیماتیو یمرگ C ار 3 فرصم هتفه رد راب دندومن . هنومن و لبق اتشان ینوخ ياه 48 هلخادم نیرخآ زا سپ تعاس اه عم...

تاسياقلما فلتخم ىلع ءوضلا ضعب ءاقلإ تم ةعجارلما هذه يف دضتسلماب دضلا تلاعافت ىلع دمتعت يتلا ةموسولما ةيعانلما ةيعانلما و ،ةيقلأتلا ةيعانلما تاسايقلما لمشت يتلاو Ag-Ab هذه فيرعت تم .)EIA, ELISA( ةييمزنلإا ةيعانلما و ،ةيعاعشلا و تلاعافتلا أدبلم رصتخم فصو عم لًاوأ ةثلاثلا تاسياقلما اهروطت حيضوتل يخيراتلا جردتلا بسح تشقون مث ،تاقيبطتلا امك .لماك لكشب ةيلآ ةينقت ىلإ ةياهنلا يف داق يذلا يجيردتلا ةخطلل...

Address: Department of Gynecology and Obstetrics, Montasariya Infertility Center, Mashhad University of Medical Sciences, Mashhad, Iran Tel: +98 511 8534021 Email: [email protected] همدقم : ناـمز رد نز بارطـضا حطـس لـثم يرـيغتم لـماوع هب هتسباو دناوت يم يروراب كمك نامرد تيقفوم دشاب نامرد . راب نانز بارطضا و يگدرسفا ريثات يبايزرا يارب هعلاطم نيا يروراـب كـمك ناـمرد دمايپ رب رو تسا هدش يحارط ...

Defects in promoters of the nonexpressed DQA2, DQB2, and DOB genes from the class II major histo-compatibility complex were mapped by placing Z and X boxes of these silent genes into a synthetic DRA promoter. These conserved upstream sequences confer B-cell-specific and gamma-interferon-inducible expression to the DRA gene. Since DRA promoters containing the X box from the DQA2 gene and Z boxes...

همدقم : نیئتورپ S100B ورون طابترا لرتنک رد و دوش یم دازآ اه تیسورتسآ زا هک تسا ینیئتورپ ، لگ ی یلا دراد شـقن یسپانیس يریذپ لکش و هظفاح رد لاامتحا و . هـعلاطم ادروخرب یصاخ تیمها زا نورون و تیسورتسآ لولس ود يدرکلمع طابترا تسا ر . ياـه شوـم رد يریگداـی يور رـب پـماکوپیه نورد هـب نیئتورـپ نیا قیرزت رثا رضاح هعلاطم رد تفرگ رارق یسررب دروم ییارحص . شور اه : زا قیقحت نیا رد 40 دش هدافتسا رن ییا...

Southern hybridisation was used to define an apparent gene duplication event at the ovine DQA2 locus. Approximately 500 sheep from five different breeds were genotyped at their DQA1 and DQA2 loci. A subset of these were selected for further characterisation. Southern hybridisation of TaqI digested DNA revealed no DQA1 region in some sheep. It was also noted in these DQA1 null animals the DQA2 s...