introduction: this study aimed to investigate the diurnal intraocular pressure fluctuations under dehydration conditions and the relationship between the intraocular pressure fluctuations and blood pressure. methods: the intraocular pressures (iop), body weights, as well as systolic and diastolic blood pressures (sbp, dbp) of 36 fasting healthy volunteers were recorded at 8:00 a.m. and 5:00 p.m...

Introduction: This study aimed to investigate the diurnal intraocular pressure fluctuations under dehydration conditions and the relationship between the intraocular pressure fluctuations and blood pressure. Methods: The intraocular pressures (IOP), body weights, as well as systolic and diastolic blood pressures (SBP, DBP) of 36 fasting healthy volunteers were recorded at 8:00 a.m. and 5:00 p.m...

PURPOSE To correlate the ibopamine provocative test with the diurnal tension curve (highest intraocular pressure-IOP and range) in glaucoma. METHODS This is a prospective case series including glaucoma patients from the Federal University of Goiás, Glaucoma Service. Two 2% ibopamine eyedrops were instilled into one or both eyes of each patient, 5 minutes apart. Intraocular pressure was checke...

OBJECTIVES To investigate the correlation and agreement between the intraocular pressure peaks detected during the water drinking test and the modified diurnal tension curve in untreated glaucomatous eyes. INTRODUCTION It has been suggested that the intraocular pressure peaks detected during the water drinking test predict the peaks observed during a 24-hour diurnal tension curve. A more feas...

Purpose The diurnal cycling of intraocular pressure (IOP) was first described in humans more than a century ago. This cycling is preserved in other species. The physiologic underpinning of this diurnal variation in IOP remains a mystery, even though elevated pressure is indicated in most forms of glaucoma, a common cause of blindness. Once identified, the system that underlies diurnal variation...

OBJECTIVE To verify the 24-hour repeatability of diurnal intraocular pressure patterns in glaucomatous and ocular hypertensive individuals. METHODS A prospective analysis of 88 eyes from 88 ocular hypertensive or open-angle glaucoma patients was conducted on diurnal tension curves obtained by the same examiner on two consecutive days. The intraclass correlation coefficient test was used for s...

The parallel, randomized, double-masked, activecontrolled trial is generally thought to be the most rigorous and unbiased design to adequately compare two glaucoma medicines. Important to this design is the intraocular pressure entry criteria. The lower limit of intraocular pressure is usually set at least >21 mmHg to help assure the study population has the appropriate diagnosis (ocular hypert...

Diurnal fluctuation of intraocular pressure (IOP) is an important issue in managing glaucoma, yet its bases are not well understood. Delineating the genetic controllers and physiological pathways may open the door to potential therapeutic targets. Miller and associates have provided evidence for a GPR18 role in the diurnal regulation of IOP in mice and explored the related endocannabinoid pathw...