Nuclear fragmentation is a common feature in many neurodegenerative diseases, including Alzheimer's disease (AD). In this study, we show that nuclear lamina dispersion is an early and irreversible trigger for cell death initiated by deregulated Cdk5, rather than a consequence of apoptosis. Cyclin-dependent kinase 5 (Cdk5) activity is significantly increased in AD and contributes to all three ha...

The recently derived theoretical threshold function associated with the autoconversion process is generalized to account for the effect of the relative dispersion of the cloud droplet size distribution. This generalized threshold function theoretically demonstrates that the relative dispersion, which has been largely neglected to date, essentially controls the cloud-to-rain transition if the li...

PURPOSE This study examined vowel characteristics in adult-directed (AD) and infant-directed (ID) speech to children with hearing impairment who received cochlear implants or hearing aids compared with speech to children with normal hearing. METHOD Mothers' AD and ID speech to children with cochlear implants (Study 1, n=20) or hearing aids (Study 2, n=11) was compared with mothers' speech to ...

Multipath routing is a technique that allows tra c dispersion and so, through the use of load-balancing, nodes energy consumption minimization or analysis for tra c prevention, it is capable to improve performance in mobile ad hoc networks. In this work we compare multipath version for two reactive protocols: DYMO and DSR. We study the impact of tra c dispersion on both UDP and TCP tra c. Moreo...

In this work the ensemble Kalman filter (EnKF) is applied to investigate the flow and transport processes at the macro-dispersion experiment (MADE) site in Columbus, MS. The EnKF is a sequential data assimilation approach that adjusts the unknown model parameter values based on the observed data with time. The classic advection–dispersion (AD) and the dual-domain mass transfer (DDMT) models are...

We use S-duality and planarity to propose an argument for the non-renormalization of the dispersion relation of giant magnon solutions in type IIB string theory on Ad S5 × S5. We compute the spectrum of giant magnons for (p, q)-strings from field theory at strong coupling by using the central charge properties of electrically and magnetically charged supersymmetric states in the Coulomb branch ...

“Anywhere” and, in particular, “anyhow”: these are the two best words that can describe an ad hoc wireless network that is due to the increasing demand for connectivity in such an information society. Ad hoc wireless networks can be described as dynamic multihop wireless networks with mobile nodes. However, the mobility condition can be relaxed, and we can consider an ad hoc wireless network as...

This observational study examined whether emotional expressivity and emotional flexibility differed between parent-child dyads with and without children with an anxiety disorder (AD). Effects of parents' own AD on emotional expressivity and flexibility of dyads was also studied. The sample consisted of 128 referred children (59.4% girls) with an AD (8-18-year-olds) and both of their parents, an...

Many ad hoc networks including military networks have a wide range of deployment densities Further they exhibit mobility patterns that induce continual and rapid density changes for instance due to the con uence and dispersion of troops Most ex isting ad hoc networking protocols tacitly or explicitly ignore density variations In this paper we discuss the performance degradation caused by densit...

Copy number variants (CNVs) of the chromosomal locus 16p11.2, consisting of either deletions or duplications, have been implicated in autism, schizophrenia, epilepsy, and other neuropsychiatric disorders. Since abnormal white matter microstructure can be seen in these more broadly defined clinical disorders, we used diffusion magnetic resonance imaging and tract-based spatial statistics to inve...