background: disorders of sex development (dsds) belong to uncommon pathologies and result from abnormalities during gonadal determination and differentiation. various gene mutations involved in gonadal determination and differentiation have been associated with gonadal dysgenesis. despite advances in exploration of genes and mechanisms involved in sex disorders, most children with severe 46,xy ...

CONTEXT Disorders of sex development (DSDs) may arise from genetic defects in testis or ovary determination. Current analytical technologies and improved understanding of major regulatory pathways have cast new insight into the genetic basis for these disorders. EVIDENCE ACQUISITION A PubMed search was performed for the years 2011-13 using the terms "disorder of sex development," "gonadal dys...

background the pre-marital sex and live-in relationship among young people are increasing at an alarming rate. remote consequences of such high risk behaviors are increase in the incidence of stds (including hiv), unsafe and illegal abortion, adolescent pregnancy and motherhood, single mother child/abandoned child, juvenile delinquency and many more. objectives the aim of this study was to inve...

Background: Disorders of sex development (DSDs) belong to uncommon pathologies and result from abnormalities during gonadal determination and differentiation. Various gene mutations involved in gonadal determination and differentiation have been associated with gonadal dysgenesis. Despite advances in exploration of genes and mechanisms involved in sex disorders, most children with severe 46,XY ...

the main disorder are due to sex chromosomal aberration comprising 2644(82.5%), cases ranging from 1211  klinefelter followed by 1025 turner  syndrome, 345 triple x, 49 double y and 14 cases of xx male. the second group consists 116 cases of gonadal dysgenesis bearing 0.042 risk of malignant transformation for xy gonadal dysgenesis. the 3rd group is hormonal defects consisting 29 cases of conge...

normal sex differentiation is the result of long ways and different steps that consecutively take place under the control of relevant enzymes resulting in a normal female or male. any effective agent and excess or deficit of the relevant enzymes result in the disorder of sex development. the main factors that affect sex development include chromosomal aberration, gonadal dysgenesis, and hormona...

Introduction Sexual differentiation is the process of development of the differences between male and female from an undifferentiated zygote (fertilised egg). Sex and gender are both important determinants of health. The term “gender” describes those characteristics of females and males that are largely socially created, whereas “sex” encompasses those characteristics that are biologically dete...