background: the present study investigated the functional maturity of oligodendrocyte derived from rat bone marrow stromal cells (bmsc). methods: the bmsc were isolated from female sprague-dawley rats and evaluated for different markers, such as fibronectin, cd106, cd90, oct-4 and cd45. transdifferentiation of olc from bmsc was obtained by exposing the bmsc to dmso and 1 µm all-trans-retinoic a...

conclusions this study shows that bdnf and ngf expression decreases in diabetic neuropathy. however, this decrease can be reversed through endurance training. these results also indicate that endurance training may have a potential role in compensating for neurotrophin deficiency following diabetic neuropathy. objectives this experimental study was designed and carried out at the tarbiat modare...

conclusions tissue engineering may open a new window in cleft palate reconstruction. stem cells and growth factors play key roles in this field. results we reported a summary of the key-points concerning cleft palate development, the genes involving this defect, current therapeutic strategies, recently novel aspects, and future advances in treatments for easy and fast understanding of the conce...

Introduction  Insulin-like growth factor I (IGF-I) which is produced in abundance in the normal adult liver, is deeply involved in hepatocyte survival, growth, and differentiation during liver development. IGF-I plays the roles via the receptor (IGF-IR) signaling pathway. IGF-IR unlike IGF-I is expressed strongly in the developing liver, but much more weakly in adults. Objective:  We hypothesi...

background and aims. plasma rich in growth factors (prgf) is a concentrated suspension of growth factors, which is used to promote periodontal tissue regeneration. the aim of this randomized, controlled, clinical trial was to evaluate of the treatment of grade ii mandibular molar furcation involvement using autogenous bone graft with and without prgf. materials and methods. in this double-blind...

abstract background autologus platelet gel is easy to prepare and is relatively low cost. the aim of this study was to prepare and evaluate in vitro efficacy of autologus platelet gel. materials and methods in this experimental study, platelet concentrate and platelet poor plasma were prepared with aphaeresis method. thrombin was prepared by mixing the plasma with calcium. thrombin activity lev...