background: a great deal of evidence has indicated that oxidatively modified ldl plays a critical role in the initiation and progression of atherosclerosis. antioxidants that can prevent ldl oxidation may act as antiatherogens. copper is a candidate for oxidizing ldl in atherosclerotic lesions. the binding of copper ions to ldl is usually thought to be a prerequisite for ldl oxidation by copper...

antioxidant consumption has been reported to be inversely associated with the incidence of coronary artery disease. to clarify the possible role of vitamin e and volatile oils in the prevention of atherosclerosis, the effects of these compounds on the susceptibility of low-density lipoprotein (ldl) to oxidative modification were investigated. in this study, vitamin e and seven volatile oils “an...

the oxidative modification of low density lipoprotein (ldl) may play an important role in atherogenesis. antioxidants that can prevent ldl oxidation may act as antiatherogens. our understanding of the mechanism of ldl oxidation and factors that determine its susceptibility to oxidation is still incomplete. copper is a candidate for oxidizing ldl in atherosclerotic lesions. the binding of copper...

background: it is well established that oxidative modification of low density lipoprotein (ldl) plays a causal role in human atherogenesis and the risk of atherosclerosis is increased in patients with diabetes mellitus. we examined the in vitro effect of glucose on native and glycated ldl oxidation using copper ion dependent oxidation system. methods: in this study, ldl was isolated from plasma...

oxidation of low density lipoprotein (ldl) has been strongly implicated in the phathogenesis of atherosclerosis. the use of oxidants in dietary food stuff may lead to the production of oxidized ldl and may increase both the development and the progression of atherosclerosis. the present work investigated the effects of some elements including: copper (cu), iron (fe), vanadium (v) and titanium (...

Lipoprotein oxidation is a key early stage in the development of atherosclerosis. Oxidation of low-density lipoprotein (LDL) is initiated by both enzyme-mediated and non-enzymic mechanisms in vivo, and oxidized LDL has many atherogenic properties. Oxidation of LDL in vivo is likely to be influenced by local environmental factors, such as pH. The composition of LDL is also important, including s...

Increased lipid peroxidation products were detected in a lipoprotein fraction containing very low density lipoprotein (VLDL) and low density lipoprotein (LDL) obtained from rats made diabetic by streptozotocin injection. The enhanced oxidation in the diabetic VLDL plus LDL fraction correlated with the in vitro toxicity of this lipoprotein fraction to proliferating fibroblasts. In contrast, high...

Background: Oxidative modification of low-density lipoprotein (LDL) appears to be an early step in the pathogenesis of atherosclerosis. Meanwhile, myeloperoxidase (MPO)-catalyzed reaction is one of the potent pathway for LDL oxidation in vivo. The aim of this study was to evaluate in vitro antioxidant effects of vitamins C and E on LDL oxidation mediated by MPO. Methods: MPO was isolated from f...

High density lipoproteins (HDL) have been reported to inhibit oxidation of low density lipoproteins (LDL) based in part on observations that oxidative changes occur more slowly in LDL-HDL mixtures than in LDL alone. In the current studies, we developed an approach to discern particle-specific oxidation kinetics within mixed particle systems using the oxidation-labile fluorescent probe parinaric...

background: oxidative modification of low-density lipoprotein (ldl) appears to be an early step in the pathogenesis of atherosclerosis. meanwhile, myeloperoxidase (mpo)-catalyzed reaction is one of the potent pathway for ldl oxidation in vivo. the aim of this study was to evaluate in vitro antioxidant effects of vitamins c and e on ldl oxidation mediated by mpo. methods: mpo was isolated from f...