a clinical presentation of a metabolic disorder, often first seen in infants who present with poor feeding, vomiting, tachypnea, acidosis, hyperammonemia, ketosis, ketonuria, irritability, and convulsions or hypotonia and lethargy, findings that are otherwise suggestive of neonatal sepsis diseases with oa isovaleric and propionic acidemias, maple syrup urine disease, medium chain acyl dehydroge...

A central feature of the osteoarthritic disease process involves erosive destruction of the articular cartilage extracellular matrix (ECM) on the surfaces of diarthrotic joints. The resultant loss of joint function makes studies on mechanisms underlying ECM degradation critical for treatment of the disease and prevention of disability. Candidate pathways to account for the loss of cartilage inv...

Ponds in agricultural areas are ubiquitous water retention systems acting as reactive biogeochemical hotspots controlling pesticide dissipation and transfer at the catchment scale. Several issues need to be addressed order understand, follow-up predict role of ponds limiting In this review, we present a critical overview functional processes underpinning ponds. We highlight distinguish degradat...

The most commonly encountered cyanobacterial toxins in freshwater are microcystins. Microcystins are extremely stable and resistant to chemical hydrolysis or oxidation and can cause illness or death in animals and humans. In this study, a total of 15 bacterial strains were isolated and screened for microcystin degradative activity from Kaen Nakhon Lake, Khon Kaen Province, Thailand. Among these...

Two classes of mutations were identified in the degS and degU regulatory genes of Bacillus subtilis, leading either to deficiency of degradative enzyme synthesis (degS or degU mutations) or to a pleiotropic phenotype which includes overproduction of degradative enzymes and the loss of genetic competence (degS(Hy) or degU(Hy) mutations). We have shown previously that the DegS protein kinase and ...