Identifying structural determinants of human immunodeficiency virus (HIV) neutralization is an important component of rational drug and vaccine design. We used cryoelectron tomography and atomic force microscopy to characterize the structure of an extremely potent HIV-neutralizing protein, D1D2-Ig alpha tp (abbreviated as D1D2-IgP), a polyvalent antibody construct that presents dodecameric CD4 ...

The aim of the present study was to investigate the correlations and possible synergy among the urokinase‑type plasminogen activator receptor (uPAR) isomer D1D2 and integrin α5β1 expression levels, malignant transformation in hepatic cells and the occurrence of liver cancer. The expression site and concentration of uPAR (D1D2) were analyzed using polymerase chain reaction and in situ hybridizat...

Infection of Escherichia coli by filamentous bacteriophages is mediated by the minor phage coat protein g3p and involves two distinct cellular receptors, the F' pilus and the periplasmic protein TolA. Recently we have shown that the two receptors are contacted in a sequential manner, such that binding of TolA by the N-terminal domain g3p-D1 is conditional on a primary interaction of the second ...

A first experiment in 229 barrows examined the effect of the genetic type on growth, carcass composition and intramuscular fat (IMF) content and composition. Four genetic types were used: Landrace x Large White (LSLW), Duroc, either inseminated with boars from the same (D1D1) or a different line (D1D2), and Duroc x Iberian (D1IB). All pigs were reared until 200 days under the same conditions. I...

The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F, and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs (snRNAs). These proteins share a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. Cry...

Dental caries is a common childhood disease and important health problem in the United States and throughout the world. Most studies that have assessed risk factors for dental caries focused on non-modifiable risk factors such as previous caries experience and socioeconomic status. It is also important to investigate modifiable risk factors that can be used in developing guidelines for risk ass...

The recent whole-genome sequencing of soybean (Glycine max) revealed that soybean experienced whole-genome duplications 59 million and 13 million years ago, and it has an octoploid-like genome in spite of its diploid nature. We analyzed a natural green-cotyledon mutant line, Tenshin-daiseitou. The physiological analysis revealed that Tenshin-daiseitou shows a non-functional stay-green phenotype...

In the context of the degree/diameter problem for directed graphs, it is known that the number of vertices of a strongly connected bipartite digraph satisfies a Moore-like bound in terms of its diameter k and the maximum out-degrees (d1; d2) of its partite sets of vertices. It has been proved that, when d1d2 > 1, the digraphs attaining such a bound, called Moore bipartite digraphs, only exist w...

Cantor’s diagonalization idea: reminder. Most mathematicians are familiar with diagonalization from Cantor’s proof that the set of all real numbers is not countable. Indeed, if it was countable, i.e., if we could enumerate all (decimal) real numbers d1d2 . . . di.f1 . . . fj . . . into a sequence d (k) 1 d (k) 2 . . . d (k) i .f (k) 1 . . . f (k) j . . ., k = 1, 2, . . ., then we would be able ...

Let G be a finite abelian group of order n. For a complex valued function f on G let f̂ denote the Fourier transform of f . The classical uncertainty inequality asserts that if f 6= 0 then |supp(f)| · |supp(f̂)| ≥ |G| . (1) Answering a question of Terence Tao, the following improvement of (1) is shown: Theorem: Let d1 < d2 be two consecutive divisors of n. If d1 ≤ k = |supp(f)| ≤ d2 then |supp(f̂)...