نتایج جستجو برای: d.b.h

تعداد نتایج: 1627  

Journal: :PloS one 2016
Joseph F Cubells Jason P Schroeder Elizabeth S Barrie Daniel F Manvich Wolfgang Sadee Tiina Berg Kristina Mercer Taylor A Stowe L Cameron Liles Katherine E Squires Andrew Mezher Patrick Curtin Dannie L Perdomo Patricia Szot David Weinshenker

Dopamine β-hydroxylase (DBH) converts dopamine (DA) to norepinephrine (NE) in noradrenergic/adrenergic cells. DBH deficiency prevents NE production and causes sympathetic failure, hypotension and ptosis in humans and mice; DBH knockout (Dbh -/-) mice reveal other NE deficiency phenotypes including embryonic lethality, delayed growth, and behavioral defects. Furthermore, a single nucleotide poly...

2016
Matthew R. Evans Aristides Moustakas

Woodlands provide valuable ecosystem services, and it is important to understand their dynamics. To predict the way in which these might change, we need process-based predictive ecological models, but these are necessarily very data intensive. We tested the ability of existing datasets to provide the parameters necessary to instantiate a well-used forest model (SORTIE) for a well-studied woodla...

2012
Meriem Gaval-Cruz Larry Cameron Liles Paul Michael Iuvone David Weinshenker

The anti-alcoholism medication, disulfiram (Antabuse), decreases cocaine use in humans regardless of concurrent alcohol consumption and facilitates cocaine sensitization in rats, but the functional targets are unknown. Disulfiram inhibits dopamine β-hydroxylase (DBH), the enzyme that converts dopamine (DA) to norepinephrine (NE) in noradrenergic neurons. The goal of this study was to test the e...

2015
Jin-lan Huang Ting-yu Ren Shun-wang Cao Shi-hao Zheng Xiu-mei Hu Yan-wei Hu Li Lin Jing Chen Lei Zheng Qian Wang

Accumulating evidence supports an important role for the hepatitis B virus x protein (HBx) in the pathogenesis of hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC), but the underlying mechanisms are not entirely clear. Here, we identified a novel long noncoding RNA (lncRNA) DBH-AS1 involved in the HBx-mediated hepatocarcinogenesis. The levels of DBH-AS1 were positively correlated w...

Journal: :Human molecular genetics 2014
Maja Mustapic Adam X Maihofer Manjula Mahata Yuqing Chen Dewleen G Baker Daniel T O'Connor Caroline M Nievergelt

Dopamine beta-hydroxylase (DBH) is the biosynthetic enzyme catalyzing formation of norepinephrine. Changes in DBH expression or activity have been implicated in the pathogenesis of cardiovascular and neuropsychiatric disorders. Genetic determination of DBH enzymatic activity and its secretion are only incompletely understood. We began with a genome-wide association search for loci contributing ...

2014
Maja Mustapic Adam X. Maihofer Manjula Mahata Yuqing Chen Dewleen G. Baker Daniel T. O’Connor Caroline M. Nievergelt

Dopamine beta-hydroxylase (DBH) is the biosynthetic enzyme catalyzing formation of norepinephrine. Changes in DBH expression or activity have been implicated in the pathogenesis of cardiovascular and neuropsychiatric disorders. Genetic determination of DBH enzymatic activity and its secretion are only incompletely understood. We began with a genome-wide association search for loci contributing ...

Journal: :The Journal of biological chemistry 2003
Suzan Dziennis Beth A Habecker

Cholinergic differentiation factors (CDFs) suppress noradrenergic properties and induce cholinergic properties in sympathetic neurons. The CDFs leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) bind to a LIFR.gp130 receptor complex to activate Jak/signal transducers and activators of transcription and Ras/mitogen-activated protein kinases signaling pathways. Little is know...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تربیت مدرس - دانشکده مهندسی عمران 1388

چکیده روش های متعددی برای برآورد رواناب حاصل از بارش در حوضه های آبریز وجود دارد. یکی از این روش ها استفاده از مدل های هیدرولوژیکی است. با استفاده از مدل های هیدرولوژیکی و شبیه سازی فرآیندهای هیدرولوژیکی می توان با صرف کمترین زمان و هزینه، رواناب و مولفه های دیگر چرخ? هیدرولوژیکی را برآورد کرد. از آنجا که در حوضه های آبریز اندازه گیری تمام کمیت های مورد نیاز برای تحلیل رواناب ممکن نیست، انتخاب...

Journal: :Annals of clinical and laboratory science 1979
M A Brewster D H Berry

Investigation of dopamine-beta-hydroxylase (DBH) serum activity as a potential diagnostic/prognostic tool for neuroblastoma did not confirm previous reports. However, age-dependent differences in normal children's DBH "activation" by water dilution +/- copper addition was revealed. These findings of age-related DBH effector differences suggest that the strong age relationship of DBH activity ma...

2010
Yangha Kim Eun-Ha Choi Miae Doo Joo-Yeon Kim Chul-Jin Kim Chong-Tai Kim In-Hwan Kim

Catecholamines are among the first molecules that displayed a kind of response to prolonged or repeated stress. It is well established that long-term stress leads to the induction of catecholamine biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine β-hydroxylase (DBH) in adrenal medulla. The aim of the present study was to evaluate the effects of ginseng on TH and DBH mRNA expre...

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