background: holothuroids (sea cucumbers) are members of the phylum echinodermata, which produce saponins. saponins exhibit a wide spectrum of pharmacological and biological activities. in this study, we isolated the crude saponins from the body wall of the dominant iranian species of sea cucumber, holothuria leucospilota (h. leucospilota). the purpose of this study was to confirm the presence o...

background: despite the wide range of applications, there is a serious lack of information on the impact of the nanoparticles on human health and the environment. the present study was done to determine the range of dangerous concentrations of iron oxide nanoparticle and their effects on mouse embryonic stem cells. methods: iron oxide nanoparticles with less than 20 nanometers diameter were enc...

cancer is a major global problem and is the second leading cause of mortality in the developed countries.resistance to current chemotherapeutics and high incidence of adverse effects are the two principal reasons for developing new anticancer agents. phenylacetamide derivatives can act as potential anticancer agents. synthesis and screening of 2-(4-fluorophenyl)-n-phenylacetamide derivatives in...

iran has 1260 km of coastline that borders the persian gulf and the oman sea in the northwest indian ocean. marine algae are one of the natural resources in the marine ecosystem which produce a wide range of new secondary metabolites with various biological activities that play an important role in the pharmaceutical care. in this study the cytotoxic activity of 28 marine algae of chabahar coas...

objective(s): nanomaterials, especially silver nanoparticles (ag-nps), are employed in an increasing number of commercial products. this has led to an ever growing exposure of human beings to this substance. the first purpose of the nano committee of food and drug administration of the islamic republic of iran (ifda) is developing guidelines to assess and approve commercial nano-health products...

introduction: this study aimed to compare the cytotoxicity of mta fillapex, ah-26 and apatite root canal sealers at different times after mixing. methods and materials: in this in vitro study, mta fillapex, ah-26 and apatite root canal sealer were spilled uniformly by 40 µm mesh in a 96-well plate. then, human fetal foreskin fibroblast cell line (hfff2) were added to each sealer cell culture me...

doxorubicin is a broad spectrum antibiotic used in the treatment of cancers. its dose dependent cardiotoxicity is the most serious side effect causing withdrawal of drug from hard chemotherapeutic regimen. statins are shown to be cytotoxic in concentrations higher than the effective doses for the treatment of hypercholesterolemia (40 mg/day). co-administration of statins and chemotherapeutic ag...

background cancer is one of the leading causes of human death. the discovery of new generations of low-cost anticancer drugs with high efficacy and low toxicity is necessary, and is only possible by screening medicinal plants with prior knowledge. objectives in this study, the bioactivities of three medicinal plants from india, including alstonia scholaris, alstonia venenata, and moringa oleife...

nowadays, growing interest in the application of nanotechnology in biomedical and biotechnological fields has opened a new avenue to explore the nanoparticles-biological system interaction. indeed, a clear gap is still in the cytotoxic effect of nps on the biological systems. for this purpose, the interaction of the silica oxide nanoparticles (sio2-np) with pc12 cell line, as a model of nervous...

introduction: the aim of this study was to evaluate the cytotoxicity of a new nano zinc-oxide eugenol (nzoe) sealer in comparison with ah-26 and pulpdent root canal sealers. methods and materials: the l929 mouse fibroblast cells were cultivated and incubated for 24, 48 or 72 h with different dilutions (1/1, 1/2, 1/4, 1/8, 1/16 and 1/32) of culture media previously exposed to either of the test ...