A 72 year old woman presented with a suspected myocardial infarction. An echocardiograph showed no acute changes but her plasma creatine kinase (CK) activity was increased at 343 U/l (< 175 normal range). The apparent creatine kinase-MB activity by a CK-M subunit immunoinhibition assay was 350 U/l. In view of the discrepancy between the total creatine kinase and CK-MB activity plasma creatine k...

Macro creatine kinase (Macro CK), a macro enzyme, is a major cause of misdiagnosis of myocardial infarction upon determination of total creatine kinase and creatine kinase isoenzyme levels. It presents in elderly female patients with an approximate prevalence of 1 %. Based on composition, there are two major types of macro CK Type 1 macro CK is a complex of Type 1 being an immune complex of cre...

Creatine Kinase and the Correlates of Blood Pressure in a Random Population Sample To the Editor: We hypothesized that creatine kinase (CK), the central regulatory enzyme of energy metabolism, amplifies blood pressure responses, and subsequently showed that CK activity is independently associated with blood pressure.1 CK catalyzes the reversible transfer of the high-energy phosphate moiety (P) ...

Aim: The aim of the study was to investigate the effects of in vitro hemolysis on serum creatine kinase and creatine kinase MB isoenzyme activities with creatine kinase MB mass, troponin I and myoglobin measurements. Materials and methods: We prepared serum pools having analyte concentrations at normal and pathological values. Hemolysate was added into serum pools to obtain aliquotes with final...

Alterations in the competency of the creatine kinase system elicit numerous structural and metabolic compensations, including changes in purine nucleotide metabolism. We evaluated molecular and kinetic changes in AMP deaminase from skeletal muscles of mice deficient in either cytosolic creatine kinase alone (M-CK-/-) or also deficient in mitochondrial creatine kinase (CK-/-) compared with wild ...

Abbreviations: GSTs: Glutathione S-Transferases; DM: Myotonic Dystrophy; PROMM: Proximal Myotonic Myopathy; ROS: Reactive Oxygen Species; Ile: Isoleucine; Val: Valine; EMG: Electromyographia; NCV: Nerve Conduction Velocity; OD: Optical Density; SNP: Single Nucleotide Polymorphisms; LWD: Learning and Writing Disability; SLD: Speech and Languages Disability; SCK: Serum Creatine Kinase; CK-MM: Cre...

OBJECTIVES We examined whether unloading of the left ventricle with a ventricular assist device (LVAD) can result in normalization of the creatine kinase (CK) abnormalities in the failing human heart. BACKGROUND Left ventricular failure is associated with a decrease of myocardial total CK activity and a fetal shift in CK isoform expression that results in an increase in the cytosolic brain ty...

ultiple etiological factors have to be considered when faced with isolated elevation of Creatine Kinase-MB (CK-MB), an isoenzyme of Creatine Kinase (CK) without any change in total CK or increase in Troponin. These factors must be kept in mind before diagnosing a patient with acute coronary syndrome (ACS) and subjecting them to further investigation and therapy which could involve anticoagulati...