The occurrence and development of gastric cancer are regulated by many factors result from the joint action factors. Studies have shown that ANP, NPRA, Cx43 play a vital role in proliferation migration cancer. This article reviews relationship between Atrial natriuretic peptide (ANP), receptor A (NPRA), Connexin43 (Cx43) with review aims to provide an effective reference value for scientific re...

The aim of the study was to assess distribution connexin43 (Cx43) and connexin40 (Cx40) in human bovine ciliary bodies. effect second messengers cAMP cyclic cGMP on Cx43 protein expression also investigated. Enucleated eyes (remnant after corneal transplantation) were used. Tissue preparations anterior segments have proceeded for immunohistochemical staining with polyclonal antibodies Cx40. Iso...

Cell-based therapies have great potential for the treatment of cardiovascular diseases. Recently, using a transgenic mouse model Roell et al. reported that cardiac engraftment of connexin43 (Cx43)-overexpressing myoblasts in vivo prevents post-infarct arrhythmia, a common cause of death in patients following heart attack. We carried out a similar study but in a clinically relevant context via t...

Decreasing Connexin43 (Cx43) expression and dysfunction of gap junction intercellular communication (GJIC) is associated with increasing proliferation and the grade of human glioma cells. Our group has previously reported that bFGF knockdown interferes connexin43 expression, however, the mechanisms underlying this interference remain unknown. We hypothesized that the bFGF signaling pathway may ...

background: hippocampal damages, which are accompanied by inflammation, are among the main causes of epilepsy acquisition. we previously reported that chronic intracerebroventricular (i.c.v.) injection of lipopolysaccharide (lps) modulates epileptogenesis in rats. there is a network of gap junction channels in the hippocampus that contribute to epileptogenesis. gap junction channels are formed ...

Osteoarthritis (OA) is the most common joint disease. In last years, research community has focused on understanding molecular mechanisms that led to pathogenesis of disease, trying identify different and clinical phenotypes along with discovery new therapeutic opportunities. Different types cell-to-cell communication have been proposed contribute OA progression, including mediated by connexin4...

OBJECTIVE The present studies were performed to examine the degradation of connexin43-containing gap junctions by the lysosome or the proteasome in normal and heat-stressed cultures of neonatal rat ventricular myocytes. METHODS Primary cultures were prepared from neonatal rat ventricular myocytes. Connexin43 was detected by immunoblotting, immunofluorescence, or immunoprecipitation. Gap junct...

iv CHAPTER 1. GENERAL LITERATURE REVIEW 1 1.1 Thesis Organization 2 1.2 Literature Review 2 1.2.1 Gap junction 2 1.2.2 Zebrafish Connexin43 6 1.2.3 Cell migration 7 1.2.4. Lumen formation 11 1.2.5 Significance of Cx43 function in endothelial migration or tube formation 15 CHAPTER 2. A DESCRIPTIVE AND FUNCTIONAL STUDY OF ZEBRAFISH CONNEXIN43 IN VASCULAR FORMATION 16

Connexin43 (Cx43), a major component of astrocytic gap junctions, is abundantly expressed in Bergmann glial cells (BGCs) in the cerebellum, but the function of Cx43 in BGCs is largely unknown. BGCs are specialized astrocytes closely associated with Purkinje cells. Here, we review our recent studies of the role of Cx43 in gap junctional coupling between BGCs and in cerebellar function. We genera...

Regulation of connexin43 (Cx43) expression affects cell proliferation, differentiation and apoptosis in a gap junctional intercellular communication (GJIC)-independent manner. However, the underlying mechanisms of Cx43-mediated cell cycle suppression are still poorly understood. To elucidate the molecular mechanism of Cx43-mediated cell cycle suppression, we searched for Cx43 interacting protei...