conclusions although we found a trend towards decreasing spah and improving 6mwd, no statistically significant shift were detected in our outcomes due to inadequate sample size. patients and methods a registered (irct201108257411n1), triple-blind, randomized controlled trial was performed in rasoule akram hospital, tehran, from 2009 to 2011. forty five patients with secondary pulmonary hyperten...

chronic  obstructive  pulmonary  disease (copd)  and  asthma  are  major  public  health problems, which seems to have close association with psychiatric disorders. the present study was conducted to compare the psychological status between asthmatic and copd patients and clarify the relationship with severity of pulmonary obstruction. this cross-sectional study was planned to compare the psych...

conclusions the fev1/fev6 ratio can be used as a valid surrogate for fev1/fvc in the diagnosis of airway obstruction, especially for screening purposes in high-risk populations for copd. moreover, fev6 is an acceptable alternative for fvc in detection of restrictive pattern. results this study shows that the current cut-off points used to detect obstruction and restriction can be replaced by fe...

according to significant improvements in the tissue engineering field over the past several years, lung tissue cells have recently attracted more attention due to the high prevalence and diversity in related diseases. however, selection of an appropriate cell type, screening of suitable conditions for growth and proliferation, as well as subsequent implantation into the body to repair and regen...

chronic obstructive pulmonary disease (copd) is associated with a chronic inflammatory response in airways and lung parenchyma that results in significant morbidity and mortality worldwide. cigarette smoking considered as an important risk factor plays a role in pathogenesis of disease. pneumocystis jirovecii is an atypical opportunistic fungus that causes pneumonia in immunosuppressed host, al...

pulmonary hypertension (ph) is an important cause of heart failure in chronic obstructive pulmonary disease (copd). the pro brain natriuretic peptide n-terminal (nt-probnp) has been suggested as a noninvasive marker to evaluate ventricular function. however, there is no evidence to support the use of nt-probnp in monitoring the benefits of vasodilators in copd induced ph. thus, we used nt-probn...

background: several studies have showed an increased prevalence of airflow obstruction in first degree relatives of individuals with chronic obstructive pulmonary disease (copd). considering no specific research had evaluated airway resistance in offspring of patients with severe copd, we utilized a spirometry and a impulse oscillometry (io) to evaluate this population. materials and methods: i...

background: depression and smoking decrease health status in chronic obstructive pulmonary disease (copd), but the combined effect of the two factors is unknown. this study aimed to assess the interactive effects of depression and smoking on the severity of patients with copd. methods: a prospective cohort study including 2,268 patients with copd was conducted in seven rural communities from ma...

abstract   background: chronic obstructive pulmonary disease (copd) is a major cause of morbidity and mortality, and is an important health economic problem. since 1960, there has been an increase in mortality associated with copd, especially in men. acute exacerbations form a major component of the socioeconomic burden of copd which mainly results in long-term hospitalization. despite the high...

introduction: pulmonary hyperinflation in patients with chronic obstructive pulmonary disease (copd) can increase the breathing rate and reduce diaphragmatic movements by pushing the diaphragms downward and limiting their movements; this, in fact, can affect the breathing process. the purpose of this study was to compare diaphragmatic movements in copd patients and healthy ones and to evaluate ...