Genome-editing systems such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 technology have uncovered new opportunities to model diseases chronic lymphocytic leukemia. CRISPR/Cas9 is an important means of advancing functional studies Chronic Lymphocytic Leukemia (CLL) through the incorporation, elimination and modification somatic mutations in CLL models.

chronic lymphocytic leukemia (cll) and chronic myeloid leukemia (cml) are the most common leukemias of the elderly (>43 year). however, the sequential occurrence of cml followed by cll in the same patient is extremely rare. in our report, a 52-year-old female was diagnosed with cll (type of bone marrow (bm) infiltration was nodular and interstitial) and was treated with chlorambucil. 64 months ...

Concurrent development of acute myeloid leukemia (AML) and chronic lymphocytic (CLL) is very rare. We present a case simultaneous CLL AML in patient with no prior exposure to cytotoxic agents or irradiation.

Ecthyma Gangrenosum is a severe skin disease commonly associated with Pseudomonas aeruginosa septicemia, there an increased risk of infection in patients malignancy undergoing chemotherapy notably Chronic lymphocytic leukemia (CLL). We present case report CLL patient infested by P. aeruginosa.

Abstract Stereotyped B-cell receptors (BCR) are frequent in patients with chronic lymphocytic leukemia (CLL). In cell culture and mouse models of CLL, immunogenic epitopes these BCRs were shown to trigger specific T-cell responses control development. These results suggest vaccination autologous BCR-derived peptides as a novel therapy for CLL. See related article by Rovida et al., p. 729

chronic lymphocytic leukemia (cll) remains an incurable disease that requires innovative new approaches to improve therapeutic outcome. many ferula species, including f. asa-foetida, synthesize terpenyloxy coumarins. one of these coumarins is umbelliprenin, which has been implicated with induction of apoptosis in some cancer cell lines.     in this study induction of apoptosis by umbelliprenin ...

Background: Accelerated-chronic lymphocytic leukemia (A-CLL) is a rare disease entity as it represents less than 1% of all reported cases chronic lymphoid (CLL). Moreover, most likely an under diagnosed due to its rarity and the non-standardized practice lymph node biopsy in CLL. Purpose: The aims our work are establish diagnosis A-CLL study prognosis treatment this entity. Method: here, we rep...

A 52-year-old man with chronic lymphocytic leukemia (CLL) entered the hospital because of repetitive bouts of massive hemoptysis requiring a right pneumonectomy. A bronchus intermedius-pulmonary artery fistula was found and felt to be due to necrosis of a peribronchial lymph node which was infiltrated by chronic lymphocytic leukemia cells. This represents another pulmonary complication in the c...

Chronic lymphocytic leukemia (CLL) is one of the most prevalent B-cell cancers for people over age 65. CLL commonly comorbid with trisomy 12, as reported in up to 20% cases. In our case, 12 was incidentally found on this patient. Its pathophysiology quite unclear but has played a role side effect profile CLL. Trisomy been shown have increased risk effects like thrombocytopenia, Richter transfor...