نتایج جستجو برای: ccr5 δ32
تعداد نتایج: 4214 فیلتر نتایج به سال:
BACKGROUND So far, many studies have investigated the distribution of CCR5 genotype between HIV-1 infected patients and uninfected people. However, no definite results have been put forward about whether heterozygosity for a 32-basepair deletion in CCR5 gene (CCR5-Δ32) can affect HIV-1 susceptibility. METHODS We performed a meta-analysis of 18 studies including more than 12000 subjects for wh...
زمینه و هدف: CCR5 یکی از مهمترین گیرنده‌های کموکاینی است که در فراخواندن سلول‌های ایمنی اختصاصی ضد‌ویروسی (نظیر: سلول‌های T سایتوتوکسیک و سلول‌های NK) به کبد نقش دارد.CCR5-Δ32 یک آلل با حذف 32 جفت‌بازی است که فاقد عملکرد می‌باشد. تاکنون چندین مطالعه گزارش کرده‌اند که این موتاسیون ممکن است با بهبود بیماری و یا با تداوم عفونت HBV مرتبط باشد. هدف اصلی این مطالعه مقایسه فراوانی جهش Δ32 در ژن CCR5 د...
Background and Objective: CCR5 is known as a main co-receptor in HIV infection. Many studies demonstrated that 32bp deletion in both CCR5 alleles provide natural resistance to HIV infection, so new treatment approaches are based on inducing this resistance by means of gene and cell therapies. This projects aim was the discovery of suitable candidates for new therapeutic strategies in addition t...
American cutaneous leishmaniasis (ACL) shows a wide spectrum of clinical and immunopathological manifestations. The CCR5 chemokine receptor directs the immune response to a Th1 pattern and the mutant allele of this genotype (Δ32/Δ32) results in a less effective response, thus leading to a milder inflammation. The objective of the present study was to investigate the effect of the CCR5 chemokine...
The CCR5-Δ32 mutation present in European populations is among the most prominently debated cases of recent positive selection in humans. This allele, a 32-bp deletion that renders the T-cell CCR5 receptor nonfunctional, has important epidemiological and public health significance, as homozygous carriers are resistant to several HIV strains. However, although the function of this allele in prev...
Individuals who are heterozygous for the CCR5-Δ32 mutation provide a natural model to examine the effects of reduced CCR5 expression on human immunodeficiency virus (HIV) persistence. We evaluated the HIV reservoir in 18 CCR5-Δ32 heterozygotes and 54 CCR5 wild-type individuals during suppressive antiretroviral therapy. Cell-associated HIV RNA levels (P=.035), RNA to DNA transcriptional ratios (...
The HIV-1 coreceptor CCR5 is a validated target for HIV/AIDS therapy. The apparent elimination of HIV-1 in a patient treated with an allogeneic stem cell transplant homozygous for a naturally occurring CCR5 deletion mutation (CCR5(Δ32/Δ32)) supports the concept that a single dose of HIV-resistant hematopoietic stem cells can provide disease protection. Given the low frequency of naturally occur...
CC-chemokine receptor 5 serves as the coreceptor for the HIV-1 R5 strains, which are responsible for the majority of HIV transmissions. A deletion of 32 nucleotides in the gene encoding this receptor (termed CCR5-Δ32) leads to the suppression of CC-chemokine receptor 5 presentation at the cell surface, thus impeding process of HIV entry into the cell. Individuals homozygous for the CCR5-Δ32 all...
HIV infection has not been cured by antiretroviral drugs or gene therapy, but it has been cured by a hematopoietic cell transplantation (HCT) that was performed for a patient with acute myeloid leukemia and HIV infection using peripheral blood stem cells from an adult donor homozygous for CCR5-Δ32 (CCR5-Δ32/Δ32). HIV has remained undetectable more than 6 years after discontinuation of antiretro...
objectives in the current case control study, we aimed to compare the histopathological findings of liver to the ccr5δ32 bpdel mutation profiles, expression and some other clinical findings in patients with chronic hcv infection. background the specific antiviral t cells provide cc chemokine receptor 5 (ccr5) for the immune response during the hepatitis c virus (hcv) infection. heterogenous and...
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