The high frequency, recent origin, and geographic distribution of the CCR532 deletion allele together indicate that it has been intensely selected in Europe. Although the allele confers resistance against HIV-1, HIV has not existed in the human population long enough to account for this selective pressure. The prevailing hypothesis is that the selective rise of CCR532 to its current frequency c...

Distribution of the HIV resistance CCR532 allele among Egyptians and Syrians Abdel-Halim Salem a,b, Mark A. Batzer a,∗ a Department of Biological Sciences, Biological Computation and Visualization Center, Center for Bio-Modular Multiscale Systems, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803, United States b Department of Anatomy, Faculty of Medicine, Suez Canal...

The distribution of genetic polymorphisms of chemokine receptors CCR532, CCR2-64I and chemokine (SDF1-3’A) mutations were studied in 110 Human Immunodeficiency Virus type 1 (HIV-1) seropositive individuals (seropositive group) and 139 seronegative individuals (seronegative group) from the population of the northern Brazilian city of Belém which is the capital of the state of Pará in the Brazili...

recurrent aphthous stomatitis (ras) is known as the most common chronic disease of the oral cavity, which affects a range of 5-25% of the population. ras appears to be associated with some human leukocyte antigen (hla) class ii alleles and haplotypes. this study attempts to survey the distribution of hla-drb and -dqb alleles among iranian ras patients and healthy controls. in order to evaluate ...

chemokine and chemokine receptors show several variations which may affect resistance to infectious disease. a 32 base pair deletion in the open reading frame of the human ccr5 gene (ccr5?32) results in producing a truncated antigen which fails to be presented on the surface of target cells. ccr5?32 variant is not a functional co receptor for hiv-1 entrance and delay the onset of acquired immun...

the human leukocyte antigen (hla)-g molecule is expressed in cytotrophoblast cells, adult thymic epithelial cells, erythroblasts, pancreatic islets and mesenchymal stem  cells. although, hla-g expression in allotransplanted patients is correlated with a better allograft acceptance, it is associated with an advanced grade of the tumor in cancer. in addition to the role on the immune system, hla-...

Infection with human immunodeficiency virus-1 (HIV-1) remains a major cause of premature death worldwide. In order to enter and infect immune cells, HIV-1 binds to cell surface receptors including the CCR5 chemokine receptor (Fig. 1A). A welldescribed functional polymorphism in the CCR5 gene comprises a 32-bp deletion (called CCR532) which results in a lack of the last three transmembrane domai...

the aim of the present study was the conducting of comparative analysis of allele pool of ukrainian population of thoroughbred horses and the populations from england, usa, russia and south korea using microsatellite loci of dna on the basis of our own researches and literary sources. comparative analysis of allele pool of thoroughbred populations from different countries was conducted using 6 ...

background and purpose: the identification of genetics risk factors of human diseases is very important. this study is conducted to model the allele frequencies (afs) of alzheimer’s disease. materials and methods: in this study, several candidate probability distributions are fitted on a data set of alzheimer’s disease genetic risk factor. unknown parameters of the considered distributions are ...