the social situation of medieval britain prior to its conquest by william,duke of normandy, in 1066 ad was so retarded. but, soon after that it wasprovided with such a great legal institutions and culture that, even today,give rise to a great surprise as to their magnificence, causing admirations byscholars. but, it raises queries regarding the original source of those legalinstitutions, for wh...

A new JGP study shows how a disease-causing mutation in RyR2 dramatically alters channel behavior.

Background Varicella has been known to be a harmless childhood disease. However, it has been reported that severe complications have taken place following Varicella infection, in both immunocompetent, as well as immunocompromised, individuals. Cutaneous complications of Varicella may manifest as preseptal cellulitis, albeit rarely. Report We present a case of a 4-year-old boy who presented wi...

The functional properties of KCNQ1 channels are highly dependent on associated KCNE-β subunits. Mutations in KCNQ1 or KCNE subunits can cause congenital channelopathies, such as deafness, cardiac arrhythmias and epilepsy. The mechanism by which KCNE1-β subunits slow the kinetics of KCNQ1 channels is a matter of current controversy. Here we show that KCNQ1/KCNE1 channel activation occurs in two ...

A design algorithm is derived, for a calculating minimum allowable electrical clearances in alternating and direct current “permissible” equipments, which are authorized to operate in gassy mines and tunnels under Part 18 of Title 30, Code of Federal Regulations [1]. The calculated clearances apply to operations at altitudes ranging up to 12 000 ft (3658 m) above sea level. The minimum allowabl...