There have been many treatments suggested for the management of mastalgia; one of these is the fruit extract of Vitex Agnus castus L. commonly known as Agnus castus, an extract of a deciduous shrub native to Mediterranean Europe and Central Asia. It is postulated that A. castus suppresses the stress-induced latent hyperprolactinemia which is a release of supra-physiological levels of prolactin ...

vitexagnus- castus l. [vac.] has been used in the iranian traditional medicine for the treatment of pain and swelling of uterus. in this study, gc and gc/ms analyses  were carried out for the identification of essential oil chemical components. formalin and xylene-induced ear-edema were used in order to nociception and inflammation activity. then, the possible interaction between 3drugs includi...

Vitex agnus-castus L. (Lamiaceae) is a medicinal plant historically used throughout the Mediterranean region to treat menstrual cycle disorders, and is still used today as a clinically effective treatment for premenstrual syndrome. The pharmaceutical activity of the plant extract is linked to its ability to lower prolactin levels. This feature has been attributed to the presence of dopaminergic...

OBJECTIVES To compare the efficacy and tolerability of agnus castus fruit (Vitex agnus castus L extract Ze 440) with placebo for women with the premenstrual syndrome. DESIGN Randomised, double blind, placebo controlled, parallel group comparison over three menstrual cycles. SETTING General medicine community clinics. PARTICIPANTS 178 women were screened and 170 were evaluated (active 86; ...

INTRODUCTION Vitex agnus-castus, also called vitex is aboriginal to the Mediterranean region, with long leaves, tender stem, flowers and ripening seeds. The aim of this study was to overview premenstrual, postmenstrual and infertility disorder of Vitex agnus-castus. METHODS This review article was carried out by searching studies in PubMed, Medline, Web of Science, and IranMedex databases. Th...

Vitex agnus-castus L., (Verbenaceae) traditional Chinese medicinal plant recommended for various inflammatory ailments, but its mechanism of anti-inflammatory action is still unclear. The present study reports the anti-inflammatory activities of various extracts and elucidate possible mechanism(s) with the quantification of flavonoids by RP-HPLC. The petroleum ether, ethyl acetate, methanol and...

Aims: In this research, it was aimed to determine the phenolic components of Vitex agnus‐castus L. (Chaste) samples belonging Verbenaceae family, which is one significant medicinal plants our country.Methods and Results: agnus-castus leaf flower provided from during flowering grown under Karabörtlen area (81 m) ecological conditions. Samples were then dried in a semi-shadowy airy place at room ...

Since the publication of "Application Guideline for Western Traditional Herbal Medicines as OTC Drugs" in 2007, only two European ethnopharmaceuticals, Vitis vinifera L., folium extract (Antistax) and Vitex agnus-castus L., fructus extract (Prefemin), have been approved as OTC drugs in Japan. In this review, we describe the current regulation of Western ethnopharmaceuticals in Japan, summarize ...

aims: leishmaniasis is the most prevalent vector- borne parasitic disease in iran. drug treatment is the best way to treat leishmaniasis, while the common drugs are not efficient enough and inevitable side effects limit using these drugs. the aim of this study was to analyze in vitro and in vivo activity of the methanolic extract of artemisia absinthium, vitex agnus-castus and phytolaca america...