introduction deformities of the uvula are considered as the dark area of otorhinolaryngology practice. this little and plain part of the human organism has various functions and its abnormalities might cause serious disabilities. case presentation in our case report, we present a unique deformity of the uvula in a 56-year-old woman. discussion the aim of this report was to present a very rare c...

A case report is a description of important scientific observations that are missed or undetectable in clinical trials. This includes a rare or unusual clinical condition, a previously unreported or unrecognized disease, unusual side effects to therapy or response to treatment, and unique use of imaging modalities or diagnostic tests to assist diagnosis of a disease. Generally, a case report sh...

The case report, which has a long history in medicine, has seen its fortune wax and wane with time. We discuss the challenges facing the continued survival of the case report, including the inability of journals to cope with the increased load and increased cost of publication, ethical issues, the impact factor and the rise of evidence-based medicine. We highlight the important role that the ca...

Once upon a time, case reports were the primary content of scholarly medical journals. Case reports are still common but have come to be viewed more often than not as anecdotes rather than evidence. And even though David Sackett referred to the important link between clinical expertise and external evidence,(1) the "gold standard" today is the randomized controlled clinical trial. Why is this?

Cell-free DNA testing is a recently introduced method for screening pregnant women for fetal trisomy, which is associated with some common significant genetic diseases, as well as the sex of the fetus. The case described here demonstrates the connection between the ultrasound "vanishing twin" phenomenon and the misdiagnosis of prenatal sex using cell-free DNA testing.

There has been a not-so-silent revolution in research over the last decade. Though researchers had been publishing guidelines and decrying the disarray or lack of uniform design standards for some time, evidence-based guidelines to help direct research design and publication are relatively new. The first major undertaking was CONSORT (Consolidated Standards of Reporting Trials), published in 19...

This report presents the results of treatment of two adults, at the Pain Center of Montreal General Hospital, Canada, with intravenous lidocaine for intractable orofacial pain. Repeated lidocaine infusions (1mg/kg in a bolus, followed by 4mg/kg infused over 1 hour) resulted in satisfactory pain relief in both patients, and the drug was well tolerated. Intravenous lidocaine therapy may be consid...