background: antimicrobial peptides with relative length (2-100 amino acids) and positive charge (pure charge (+9)-(+2)) are amphiphilic that isolated from a wide range of animals. recently, these peptides have been known as a part of innate immune response. nowadays, more than 500 antimicrobial peptides from animals have been reported. objectives: the aim of this study was to evaluate the anti-...

conclusions the findings show fluconazole -resistance in c. albicans isolates with overexpression of pir1p. results in the 52 isolates, 49 (94%) were resistant to fluconazole. overexpression of pir1 gene was detected in 47 (96%) fluconazole-resistant c. albicans isolates. patients and methods a total of 52l vaginal samples were obtained from the females with c. albicans vaginitis. the azole sus...

conclusions our results showed that c. albicans was the most frequently isolated from both patients with vaginitis and normal individual. in the present study, we could not find any correlation between extracellular activities and sources of isolates (patients and normal flora) and sensitivity or resistance to fluconazole. background extracellular phospholipase, proteinase, and coagulase are ac...

Background and Purpose: The frequency of opportunistic fungal infections in immunocompromised patients, especially by Candida species, has sharply increased in the last few decades. The objective of this study was to analyse the ergosterol content and gene expression profiling of clinical isolates of fluconazole resistant Candida albicans. Materials and Methods: Sixty clinical samples were ide...

Introduction: Recent epidemiological studies show that episodes due to non-albicans species of Candida (C) such as Candida tropicalis, C. glabrata, C, krusei, C. parapsilosis appear to be increasing in recurrent vulvovaginal candidiasis (RVVC). Increased use of the current antifungal drugs cause drug resistance among Candida species. In order to gain suitable antifungal therapy for this disease...

OBJECTIVE To determine the susceptibilities of Candida species isolated from Taiwan to amphotericin B and fluconazole. DESIGN Prospective surveillance study. METHODS Each hospital was asked to submit up to 10 C. albicans and 40 non-albicans Candida species during the collection period, from April 15 to June 15, 1999. One isolate was accepted from each episode of infection. The broth microdi...

Fluconazole disk-diffusion susceptibility was evaluated in 230 blood isolates and 344 non-blood clinical isolates of Candida spp. collected in 2002 at National Taiwan University Hospital. Up to 93.5% of blood isolates were susceptible to fluconazole, 3% were susceptible dose-dependent, and 3.5% were resistant. The minimum inhibitory concentrations at which 50% of tested isolates were inhibited ...

abstract       background and objectives: more candida albicans strains are reported resistant to fluconazole in patients with aids, cancer and organ recipients. fluconazole resistance can be attributed to changes in pathways of sterol biosynthesis, mutation in or overexpression of erg11 and the expression of cdr1, cdr2, and mdr1. this study aimed to compare the expression of cdr1, cdr2, and md...